用四磺基苯基钌（II）卟吩络合物对碳纳米纤维进行功能化，用于氯丙嗪的实时电流检测,Microchimica Acta

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用四磺基苯基钌（II）卟吩络合物对碳纳米纤维进行功能化，用于氯丙嗪的实时电流检测
Microchimica Acta ( IF 5.3 ) Pub Date : 2019-04-15 , DOI: 10.1007/s00604-019-3384-y
Rajalakshmi Sakthivel , Subbiramaniyan Kubendhiran , Shen-Ming Chen

摘要用钌 (II)-四磺基苯基卟啉 (CNF/Ru-TSPP) 功能化的碳纳米纤维被证明是用于安培法测定抗精神病药物氯丙嗪 (CPZ) 的可行传感器。空心片状结构的 Ru-TSPP 通过 π 堆积相互作用与 CNF 的空心圆柱管状结构相结合。电极的形态和导电性能通过分光光度技术表征。CNF/Ru-TSPP 修饰电极表现出较大的表面积与体积比、良好的电子传输和良好的电催化活性。电流传感器通常在 0.63 V（相对于 Ag/AgCl）的电位下运行，在 0.6 nM 至 1.1 mM CPZ 浓度范围内表现出线性响应，具有 0.2 nM 的检测限和非常好的电化学灵敏度 (2. 405 μA μM-1 cm-2）。该传感器具有选择性、可重复性和可再现性。成功应用于加标血清样品中CPZ的测定。碳纳米纤维/四磺基苯基钌（II）卟啉（CNF/Ru-TSPP）纳米复合材料的合成示意图以及用于电化学测定氯丙嗪（CPZ）的应用。

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Functionalization of a carbon nanofiber with a tetrasulfonatophenyl ruthenium(II)porphine complex for real-time amperometric sensing of chlorpromazine

AbstractA carbon nanofiber functionalized with ruthenium(II)-tetrasulfonato phenyl porphine (CNF/Ru-TSPP) is shown to be viable sensor for amperometric determination of the antipsychotic drug chlorpromazine (CPZ). The hollow platelet structured Ru-TSPP combines with the hollow cylindrical tube-like structure of the CNF via π stacking interaction. The morphological and electro conductive properties of the electrode were characterized by spectrophotometric techniques. The CNF/Ru-TSPP modified electrode displays a large surface-to-volume ratio, good electron transport and good electrocatalytic activity. The amperometric sensor, typically operated at a potential 0.63 V (vs. Ag/AgCl) exhibits a linear response in the 0.6 nM to 1.1 mM CPZ concentration range, has a 0.2 nM detection limit, and a remarkably good electrochemical sensitivity (2.405 μA μM−1 cm−2). The sensor is selective, repeatable and reproducible. It was successfully applied to the determination of CPZ in spiked serum samples. Graphical abstractSchematic presentation of carbon nanofiber/ tetrasulfonatophenyl Ruthenium(II)porphine (CNF/Ru-TSPP) nanocomposite synthesis and application for the electrochemical determination of chlorpromazine (CPZ).

更新日期：2019-04-15

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