Department of BioengineeringHenry Samueli School of Engineering and Applied SciencesUniversity of California‐Los Angeles Los Angeles CA 90095 USA
Center for Minimally Invasive Therapeutics (C‐MIT)University of California‐Los Angeles Los Angeles CA 90095 USA
Department of Chemistry and BiochemistryUniversity of California‐Los Angeles Los Angeles CA 90095 USA
Department of Molecular and Medical PharmacologyUniversity of California‐Los Angeles Los Angeles CA 90095 USA
Department of RadiologyDavid Geffen School of MedicineUniversity of California‐Los Angeles Los Angeles CA 90095 USA
Department of MedicineDivision of Engineering in MedicineBrigham and Women's HospitalHarvard Medical School Cambridge MA 02139 USA
Harvard‐MIT Division of Health Sciences and TechnologyMassachusetts Institute of Technology Cambridge MA 02139 USA
Department of Chemical and Biomolecular EngineeringHenry Samueli School of Engineering and Applied SciencesUniversity of California‐Los Angeles Los Angeles CA 90095 USA
In article number 1900300, Junmin Lee, Ali Khademhosseini, and co‐workers develop a nanoliter and high‐throughput drug screening platform based on the combination of microwell arrays as a cell culture substrate, and micropillar arrays for drug delivery and biomolecular detection in response to drugs. The developed platform requires only a small amount of sample volume from a few cells and demonstrates increasing control and throughput while allowing direct and real‐time on‐chip measurements. It is expected to aid in improving drug screening on patient biopsies from solid tumors to realize personalized cancer therapy.
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