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Nucleic Acid-Based Functional Nanomaterials as Advanced Cancer Therapeutics.
Small ( IF 13.0 ) Pub Date : 2019-04-11 , DOI: 10.1002/smll.201900172 Ye Yuan 1 , Zi Gu 2 , Chi Yao 1 , Dan Luo 3, 4 , Dayong Yang 1
Small ( IF 13.0 ) Pub Date : 2019-04-11 , DOI: 10.1002/smll.201900172 Ye Yuan 1 , Zi Gu 2 , Chi Yao 1 , Dan Luo 3, 4 , Dayong Yang 1
Affiliation
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Nucleic acid–based functional nanomaterials (NAFN) have been widely used as emerging drug delivery nanocarriers for cancer therapeutics. Considerable works have demonstrated that NAFN can effectively load and protect therapeutic agents, and particularly enable targeting delivery to the tumor site and stimuli‐responsive release. These outstanding performances are due to NAFN's unique properties including inherent biological functions and sequence programmability as well as biocompatibility and biodegradability. In this Review, the recent progress on NAFN as advanced cancer therapeutics is highlighted. Three main cancer therapy approaches are categorized including chemo‐, immuno‐, and gene‐therapy. Examples are presented to show how NAFN are rationally and exquisitely designed to address problems in cancer therapy. The challenges and future development of NAFN are also discussed toward future more practical biomedical applications.
中文翻译：
基于核酸的功能纳米材料作为先进的癌症治疗方法。
基于核酸的功能纳米材料（NAFN）已被广泛用作癌症治疗的新兴药物递送纳米载体。大量的研究表明，NAFN可以有效地负载和保护治疗剂，特别是能够靶向递送至肿瘤部位和刺激反应性释放。这些出色的性能归因于NAFN的独特特性，包括固有的生物学功能和序列可编程性以及生物相容性和生物降解性。在本综述中，着重介绍了NAFN作为晚期癌症治疗剂的最新进展。三种主要的癌症治疗方法包括化学疗法，免疫疗法和基因疗法。举例说明了如何合理合理地设计NAFN来解决癌症治疗中的问题。
更新日期：2019-04-11
中文翻译：
基于核酸的功能纳米材料作为先进的癌症治疗方法。
基于核酸的功能纳米材料（NAFN）已被广泛用作癌症治疗的新兴药物递送纳米载体。大量的研究表明，NAFN可以有效地负载和保护治疗剂，特别是能够靶向递送至肿瘤部位和刺激反应性释放。这些出色的性能归因于NAFN的独特特性，包括固有的生物学功能和序列可编程性以及生物相容性和生物降解性。在本综述中，着重介绍了NAFN作为晚期癌症治疗剂的最新进展。三种主要的癌症治疗方法包括化学疗法，免疫疗法和基因疗法。举例说明了如何合理合理地设计NAFN来解决癌症治疗中的问题。
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