Dynamic DNA Structures.,Small

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Dynamic DNA Structures.
Small ( IF 13.0 ) Pub Date : 2019-04-10 , DOI: 10.1002/smll.201900228
Yingwei Zhang _{1,

2} , Victor Pan ₃ , Xue Li ₁ , Xueqin Yang ₁ , Haofei Li ₁ , Pengfei Wang ₁ , Yonggang Ke ₃

Affiliation

Dynamic DNA structures, a type of DNA construct built using programmable DNA self-assembly, have the capability to reconfigure their conformations in response to environmental stimulation. A general strategy to design dynamic DNA structures is to integrate reconfigurable elements into conventional static DNA structures that may be assembled from a variety of methods including DNA origami and DNA tiles. Commonly used reconfigurable elements range from strand displacement reactions, special structural motifs, target-binding DNA aptamers, and base stacking components, to DNA conformational change domains, etc. Morphological changes of dynamic DNA structures may be visualized by imaging techniques or may be translated to other detectable readout signals (e.g., fluorescence). Owing to their programmable capability of recognizing environmental cues with high specificity, dynamic DNA structures embody the epitome of robust and versatile systems that hold great promise in sensing and imaging biological analytes, in delivering molecular cargos, and in building programmable systems that are able to conduct sophisticated tasks.

中文翻译：

动态 DNA 结构。

动态 DNA 结构是一种使用可编程 DNA 自组装构建的 DNA 构建体，能够根据环境刺激重新配置其构象。设计动态 DNA 结构的一般策略是将可重构元件集成到传统的静态 DNA 结构中，这些结构可以通过多种方法组装，包括 DNA 折纸和 DNA 瓦片。常用的可重构元件包括链置换反应、特殊结构基序、靶标结合DNA适体和碱基堆积成分，以及DNA构象变化结构域等。动态DNA结构的形态变化可以通过成像技术可视化，也可以转化为其他可检测的读出信号（例如荧光）。由于其具有高特异性识别环境线索的可编程能力，动态 DNA 结构体现了强大且多功能系统的缩影，这些系统在生物分析物的传感和成像、分子货物的输送以及构建能够执行操作的可编程系统方面具有巨大的前景。复杂的任务。

更新日期：2019-04-10

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