Ruthenium-catalyzed ortho-selective CAr–H amination of heteroaryl arenes with di-tert-butyldiaziridinone†,Chemical Communications

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Ruthenium-catalyzed ortho-selective CAr–H amination of heteroaryl arenes with di-tert-butyldiaziridinone†
Chemical Communications ( IF 4.3 ) Pub Date : 2019-04-11 00:00:00 , DOI: 10.1039/c9cc02499a
Xue-Ya Gou _{1,

2,

3,

4} , Yuke Li _{5,

6,

7,

8} , Xin-Gang Wang _{1,

2,

3,

4} , Hong-Chao Liu _{1,

2,

3,

4} , Bo-Sheng Zhang _{1,

2,

3,

4} , Jia-Hui Zhao _{1,

2,

3,

4} , Zhao-Zhao Zhou _{1,

2,

3,

4} , Yong-Min Liang _{1,

2,

3,

4}

Affiliation

Application of an oxidative amination reagent (di-tert-butyldiaziridinone) to the Ru₃(CO)₁₂-catalyzed ortho-selective C_Ar–H amination reaction is described. This strategy shows good functional group compatibility with various phenyl-substituted N-heterocycles, including biologically active substrates, thus providing synthetic potential for this methodology. Mechanistic studies showed that the reaction process involves an octahedral ruthenium species, and the carbon monoxide ligand plays a crucial role in the C–H activation.

中文翻译：

钌催化的杂芳基芳烃与二叔丁基二氮杂吡啶酮的邻位选择性C _Ar –H胺化†

描述了在Ru ₃（CO）₁₂催化的邻位选择性C _Ar –H胺化反应中使用氧化胺化试剂（二叔丁基二氮并吡啶酮）。该策略显示了与各种苯基取代的N-杂环（包括生物活性底物）的良好官能团相容性，因此为该方法提供了合成潜力。机理研究表明，反应过程涉及八面体钌物种，一氧化碳配体在C–H活化中起关键作用。

更新日期：2019-04-11

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