Rational Design of Framework Nucleic Acids for Bioanalytical Applications.,ChemPlusChem

当前位置： X-MOL 学术 › ChemPlusChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Rational Design of Framework Nucleic Acids for Bioanalytical Applications.
ChemPlusChem ( IF 3.0 ) Pub Date : 2019-04-29 , DOI: 10.1002/cplu.201900118
Yuwei Su ₁ , Dan Li ₁ , Bingyi Liu ₁ , Mingshu Xiao ₁ , Fei Wang ₂ , Li Li ₁ , Xueli Zhang _{2,

3} , Hao Pei ₁

Affiliation

With the advent of DNA nanotechnology, nucleic acids have been used building blocks for constructing various DNA nanostructures. As classical and simple DNA nanostructures, framework nucleic acids (FNAs) have attracted enormous attention in the field of biosensing. The sequence-specific self-assembly properties and high programmability of nucleic acids allow FNAs to be incorporated in advanced probe design. In addition, FNAs enable the engineering of surfaces for biosensing (e. g., probe orientation, probe spacing), thereby improving the accessibility of target molecules to the probes arranged on heterogeneous surfaces. Moreover, FNAs offer a universal and promising platform for sensing cellular molecules because of their prominent biocompatibility and cellular permeability. Herein recent advances in FNA-based biosensors are summarized, including electrochemical detection, optical detection, and intracellular sensing. It is hoped that this review will provide guidelines for the design and construction of FNA scaffold-based biosensors.

中文翻译：

用于生物分析应用的框架核酸的合理设计。

随着DNA纳米技术的出现，核酸已被用作构建各种DNA纳米结构的基础。作为经典和简单的DNA纳米结构，框架核酸（FNA）在生物传感领域引起了极大的关注。核酸的序列特异性自组装特性和高度可编程性使FNA可以纳入高级探针设计中。另外，FNA使得能够工程化用于生物传感的表面（例如，探针取向，探针间距），从而改善靶分子对布置在异质表面上的探针的可及性。此外，由于FNA具有出色的生物相容性和细胞通透性，它们为感知细胞分子提供了一个通用且有前途的平台。本文总结了基于FNA的生物传感器的最新进展，包括电化学检测，光学检测和细胞内感测。希望这次审查将为基于FNA支架的生物传感器的设计和构造提供指导。

更新日期：2019-04-29

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南