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Chinese yam (Dioscorea opposita Thunb.) alleviates antibiotic-associated diarrhea, modifies intestinal microbiota, and increases the level of short-chain fatty acids in mice.
Food Research International ( IF 7.0 ) Pub Date : 2019-04-09 , DOI: 10.1016/j.foodres.2019.04.016 Nan Zhang 1 , Tisong Liang 1 , Quan Jin 1 , Cai Shen 1 , Yifan Zhang 2 , Pu Jing 1
Food Research International ( IF 7.0 ) Pub Date : 2019-04-09 , DOI: 10.1016/j.foodres.2019.04.016 Nan Zhang 1 , Tisong Liang 1 , Quan Jin 1 , Cai Shen 1 , Yifan Zhang 2 , Pu Jing 1
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Antibiotic-associated diarrhea (AAD) is a common adverse effect of antibiotic treatment. The study was to evaluate effects of Chinese yam (Dioscorea opposita Thunb.) on AAD, and changes of intestinal microbiota and short-chain fatty acids (SCFA). AAD model was established using Balb/c mice by gavage with ampicillin for 5 days, followed by a 10-day administration of low, medium, and high dosage of Chinese yam, containing allantoin (4.35 mg/g) and polysaccharides (85.51 mg/g). The results showed that Chinese yam accelerated the recovery from acute diarrhea, reverse AAD-induced body weight loss and cecal enlargement. The high-dosage Chinese yam increased probiotic Bifidobacteria and Lactobacilli by 47% and 21% and decreased potential pathogen Enterococcus and Clostridium perfringens by 8% and 27% on day 15 (P < .05). Bacterial community analysis revealed that Chinese yam contributed to repair the ampicillin-induced intestinal microbiota disorder, enrich the abundance of Bacteroides spp. and Clostridium spp. Additionally, Chinese yam supplementation increased the production of SCFA.
中文翻译：
山药（Dioscorea opposita Thunb。）减轻了与抗生素有关的腹泻，改变了肠道菌群，并增加了小鼠短链脂肪酸的水平。
抗生素相关性腹泻（AAD）是抗生素治疗的常见不良反应。该研究旨在评估山药（Dioscorea opposita Thunb。）对AAD的影响以及肠道菌群和短链脂肪酸（SCFA）的变化。用Balb / c小鼠灌胃5天，然后用低，中，高剂量的山药灌胃10天，建立了AAD模型，其中含有尿囊素（4.35 mg / g）和多糖（85.51 mg / G）。结果表明，山药加速了急性腹泻的恢复，逆转了AAD引起的体重减轻和盲肠增大。高剂量的山药在第15天时将益生菌双歧杆菌和乳酸杆菌分别增加了47％和21％，并将潜在病原体肠球菌和产气荚膜梭菌减少了8％和27％（P <.05）。细菌群落分析表明，山药有助于修复氨苄青霉素引起的肠道菌群失调，丰富了拟杆菌的数量。和梭状芽胞杆菌。此外，补充山药增加了SCFA的产量。
更新日期：2019-04-09
中文翻译：
山药（Dioscorea opposita Thunb。）减轻了与抗生素有关的腹泻，改变了肠道菌群，并增加了小鼠短链脂肪酸的水平。
抗生素相关性腹泻（AAD）是抗生素治疗的常见不良反应。该研究旨在评估山药（Dioscorea opposita Thunb。）对AAD的影响以及肠道菌群和短链脂肪酸（SCFA）的变化。用Balb / c小鼠灌胃5天，然后用低，中，高剂量的山药灌胃10天，建立了AAD模型，其中含有尿囊素（4.35 mg / g）和多糖（85.51 mg / G）。结果表明，山药加速了急性腹泻的恢复，逆转了AAD引起的体重减轻和盲肠增大。高剂量的山药在第15天时将益生菌双歧杆菌和乳酸杆菌分别增加了47％和21％，并将潜在病原体肠球菌和产气荚膜梭菌减少了8％和27％（P <.05）。细菌群落分析表明，山药有助于修复氨苄青霉素引起的肠道菌群失调，丰富了拟杆菌的数量。和梭状芽胞杆菌。此外，补充山药增加了SCFA的产量。
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