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Development and validation of a new artificial gastric digestive system.
Food Research International ( IF 7.0 ) Pub Date : 2019-04-08 , DOI: 10.1016/j.foodres.2019.04.015 Weilin Liu 1 , Danyu Fu 1 , Xinjie Zhang 1 , Jieyu Chai 1 , Shiyi Tian 1 , Jianzhong Han 1
Food Research International ( IF 7.0 ) Pub Date : 2019-04-08 , DOI: 10.1016/j.foodres.2019.04.015 Weilin Liu 1 , Danyu Fu 1 , Xinjie Zhang 1 , Jieyu Chai 1 , Shiyi Tian 1 , Jianzhong Han 1
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The stomach is a major digestive organ of the human body that plays a role in storing, mixing, reducing chylous particles and breaking down ingested foods. This study established a new artificial gastric digestive system (AGDS) with a human stomach shape and structure by a 3D digital technology. Two sets of symmetrical rollers and one set of contrary movement of the roller were used to simulate the peristalsis of the stomach, and a pH-stat workstation was applied to control the pH. The force, pepsin and gastric juice secretion, gastric emptying and pH changes of AGDS were tacked and validated. Besides, the digestion behavior of α-lactalbumin using AGDS model, static model and semi-dynamic model (pH and enzyme changes) were studied. The results showed that the hydrolysis and morphology of protein, peptide and amino acids accumulation obtained by AGDS were different from the static digestion and semi-dynamic digestion models, indicating pH and gastric motility had certain effect on protein hydrolysis, particularly in the pepsin activity changes at early stage of digestion. AGDS, verified by mechanical analysis and in vitro digestion experiments, indicated that it can provide α-LA protein solution with a true and reliable digestion profile in the stomach, and can be used as a potential dynamic gastric digestion model for the food development.
中文翻译：
新的人工胃消化系统的开发和验证。
胃是人体的主要消化器官，在储存，混合，减少乳状颗粒和分解摄入的食物方面起着重要的作用。这项研究通过3D数字技术建立了一种具有人胃形状和结构的新型人工胃消化系统（AGDS）。使用两组对称的辊子和一组相反的辊子运动模拟胃的蠕动，并使用pH调节器工作站控制pH值。研究了AGDS的作用力，胃蛋白酶和胃液分泌，胃排空和pH变化。此外，利用AGDS模型，静态模型和半动态模型（pH和酶的变化）研究了α-乳白蛋白的消化行为。结果表明，蛋白质的水解和形态，AGDS获得的肽和氨基酸积累不同于静态消化和半动态消化模型，表明pH和胃动力对蛋白质水解有一定影响，特别是在消化初期胃蛋白酶活性的改变。通过机械分析和体外消化实验验证的AGDS表明，它可以在胃中提供真实可靠的消化特性的α-LA蛋白溶液，并可作为潜在的动态胃消化模型用于食品开发。
更新日期：2019-04-08
中文翻译：
新的人工胃消化系统的开发和验证。
胃是人体的主要消化器官，在储存，混合，减少乳状颗粒和分解摄入的食物方面起着重要的作用。这项研究通过3D数字技术建立了一种具有人胃形状和结构的新型人工胃消化系统（AGDS）。使用两组对称的辊子和一组相反的辊子运动模拟胃的蠕动，并使用pH调节器工作站控制pH值。研究了AGDS的作用力，胃蛋白酶和胃液分泌，胃排空和pH变化。此外，利用AGDS模型，静态模型和半动态模型（pH和酶的变化）研究了α-乳白蛋白的消化行为。结果表明，蛋白质的水解和形态，AGDS获得的肽和氨基酸积累不同于静态消化和半动态消化模型，表明pH和胃动力对蛋白质水解有一定影响，特别是在消化初期胃蛋白酶活性的改变。通过机械分析和体外消化实验验证的AGDS表明，它可以在胃中提供真实可靠的消化特性的α-LA蛋白溶液，并可作为潜在的动态胃消化模型用于食品开发。
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