BACKGROUND Life expectancy is reduced by 19 years in men and 17 in women with psychosis in Sweden, largely due to cardiovascular disease. AIM Assess whether a psychosocial health promotion intervention improves cardiometabolic risk factors, quality of life, and severity of illness in patients with psychotic disorders more than treatment as usual. METHODS A pragmatic intervention trial testing a manual-based multi-component health promotion intervention targeting patients with psychosis. The Swedish intervention was adapted from IMPaCT therapy, a health-promotion program based on motivational interviewing and cognitive behavioral therapy, designed to be incorporated into routine care. The intervention group consisted of 119 patients and the control group of 570 patients from specialized psychosis departments. Outcome variables were assessed 6 months before intervention during the run-in period, again at the start of intervention, and 12 months after the intervention began. The control group received treatment as usual. RESULTS The intervention had no significant effect on any of the outcome variables. However, BMI, waist circumference, systolic BP, heart rate, HbA1c, general health, and Clinical Global Impressions Scale score improved significantly during the run-in period before the start of the active intervention (observer effect). The multi-component design meant that treatment effects could only be calculated for the intervention as a whole. CONCLUSION The results of the intervention are similar to those of the U.K. IMPaCT study, in which the modular health-promotion intervention had little effect on cardiovascular risk indicators. However, in the current study, the run-in period had a positive effect on cardiometabolic risk factors.

中文翻译：

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旨在改善精神分裂症和精神病 (MINT) 患者的身体健康和减少酒精使用的心理社会健康促进干预的结果

背景 瑞典患有精神病的男性和女性的预期寿命分别减少了 19 年和 17 年，这主要是由于心血管疾病。目的 评估心理社会健康促进干预是否比常规治疗更能改善精神病患者的心脏代谢危险因素、生活质量和疾病严重程度。方法 一项务实的干预试验，测试针对精神病患者的基于手册的多组分健康促进干预。瑞典的干预措施改编自 IMPCT 疗法，这是一种基于动机访谈和认知行为疗法的健康促进计划，旨在纳入常规护理。干预组由119名患者组成，对照组由570名来自精神病专科的患者组成。在磨合期干预前 6 个月、干预开始时和干预开始后 12 个月对结果变量进行评估。对照组照常接受治疗。结果 干预对任何结果变量都没有显着影响。然而，在主动干预开始前的磨合期，BMI、腰围、收缩压、心率、HbA1c、一般健康和临床总体印象量表得分显着改善（观察者效应）。多组分设计意味着只能将干预作为一个整体来计算治疗效果。结论 干预的结果与英国 IMPACT 研究的结果相似，其中模块化健康促进干预对心血管风险指标的影响很小。然而，