The molecular and cellular mechanisms of depression: a focus on reward circuitry.,Molecular Psychiatry

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The molecular and cellular mechanisms of depression: a focus on reward circuitry.
Molecular Psychiatry ( IF 9.6 ) Pub Date : 2019-04-09 , DOI: 10.1038/s41380-019-0415-3
Megan E Fox ₁ , Mary Kay Lobo ₁

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Depression is a complex disorder that takes an enormous toll on individual health. As affected individuals display a wide variation in their clinical symptoms, the precise neural mechanisms underlying the development of depression remain elusive. Although it is impossible to phenocopy every symptom of human depression in rodents, the preclinical field has had great success in modeling some of the core affective and neurovegetative depressive symptoms, including social withdrawal, anhedonia, and weight loss. Adaptations in select cell populations may underlie these individual depressive symptoms and new tools have expanded our ability to monitor and manipulate specific cell types. This review outlines some of the most recent preclinical discoveries on the molecular and neurophysiological mechanisms in reward circuitry that underlie the expression of behavioral constructs relevant to depressive symptoms.

中文翻译：

抑郁症的分子和细胞机制：关注奖励电路。

抑郁症是一种复杂的疾病，会给个人健康带来巨大损失。由于受影响的个体在临床症状上表现出很大的差异，因此抑郁症发展的确切神经机制仍然难以捉摸。尽管不可能对啮齿动物的人类抑郁症的每种症状进行表型化，但临床前领域在模拟一些核心的情感和神经营养性抑郁症状（包括社交退缩，快感不足和体重减轻）方面取得了巨大的成功。选择的细胞群适应可能是这些个体抑郁症状的基础，而新的工具已经扩展了我们监测和操作特定细胞类型的能力。

更新日期：2019-05-16

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