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Antibacterial Porous Microcarriers with a Pathological State Responsive Switch for Wound Healing
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2019-04-15 , DOI: 10.1021/acsabm.9b00134 Canwen Chen 1 , Yuxiao Liu 2 , Lingyu Sun 2 , Guopu Chen 1 , Xiuwen Wu 1 , Jianan Ren 1 , Yuanjin Zhao 1, 2
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2019-04-15 , DOI: 10.1021/acsabm.9b00134 Canwen Chen 1 , Yuxiao Liu 2 , Lingyu Sun 2 , Guopu Chen 1 , Xiuwen Wu 1 , Jianan Ren 1 , Yuanjin Zhao 1, 2
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In this article, novel antibacterial porous microcarriers with a pathological state responsive switch were developed to promote wound healing. The porous microcarrier includes an inverse opal scaffold generated by a temperature-responsive hydrogel that deforms according to different temperatures and a biodegradable sodium alginate hydrogel used as a vehicle to load drugs. Thus, the microcarrier is endowed with the ability of releasing loaded drugs when the temperature changes in the wound site due to an inflammation reaction. Without inflammation, the microcarriers will be locked and the release of drug molecules will not continue, which prevents the abuse of drugs and further improves the safety of the therapeutic treatment. The designed microcarriers could eliminate inflammation significantly and promote the formation of granulation tissue, angiogenesis, and collagen deposition in the wound site. These features indicate that these microcarriers with a pathological state responsive switch are ideal for promoting wound healing and will have a great potential in biomedical applications.
中文翻译：
具有病理状态响应开关的抗菌多孔微载体用于伤口愈合
在本文中，开发了具有病理状态响应开关的新型抗菌多孔微载体，以促进伤口愈合。多孔微载体包括由根据不同温度变形的温度响应性水凝胶产生的反蛋白石支架和用作载药载体的可生物降解海藻酸钠水凝胶。因此，微载体被赋予了当伤口部位因炎症反应而发生温度变化时释放负载药物的能力。在没有炎症的情况下，微载体将被锁定，药物分子的释放不会继续，从而防止药物滥用，进一步提高治疗的安全性。所设计的微载体可以显着消除炎症并促进肉芽组织的形成，血管生成和伤口部位的胶原蛋白沉积。这些特征表明，这些具有病理状态响应开关的微载体是促进伤口愈合的理想选择，在生物医学应用中具有巨大潜力。
更新日期：2019-05-16
中文翻译：
具有病理状态响应开关的抗菌多孔微载体用于伤口愈合
在本文中，开发了具有病理状态响应开关的新型抗菌多孔微载体，以促进伤口愈合。多孔微载体包括由根据不同温度变形的温度响应性水凝胶产生的反蛋白石支架和用作载药载体的可生物降解海藻酸钠水凝胶。因此，微载体被赋予了当伤口部位因炎症反应而发生温度变化时释放负载药物的能力。在没有炎症的情况下，微载体将被锁定，药物分子的释放不会继续，从而防止药物滥用，进一步提高治疗的安全性。所设计的微载体可以显着消除炎症并促进肉芽组织的形成，血管生成和伤口部位的胶原蛋白沉积。这些特征表明，这些具有病理状态响应开关的微载体是促进伤口愈合的理想选择，在生物医学应用中具有巨大潜力。
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