Circular RNAs open a new chapter in cardiovascular biology.,Nature Reviews Cardiology

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Circular RNAs open a new chapter in cardiovascular biology.
Nature Reviews Cardiology ( IF 41.7 ) Pub Date : 2019-08-01 , DOI: 10.1038/s41569-019-0185-2
Simona Aufiero _{1,

2} , Yolan J Reckman ₁ , Yigal M Pinto ₁ , Esther E Creemers ₁

Affiliation

Circular RNAs (circRNAs) are emerging as a new class of non-coding RNA molecules. This unusual class of RNA species is generated by a back-splicing event of one or two exons, resulting in a covalently closed circRNA molecule. Owing to their circular form, circRNAs are protected from degradation by exonucleases and have greater stability than linear RNA. Advances in computational analysis of RNA sequencing have revealed that thousands of different circRNAs are expressed in a wide range of mammalian tissues, including the cardiovascular system. Moreover, numerous circRNAs are expressed in a disease-specific manner. A great deal of progress has been made in understanding the biogenesis and function of these circRNAs. In this Review, we discuss the current understanding of circRNA biogenesis and function, with a particular emphasis on the cardiovascular system.

中文翻译：

环状 RNA 开启了心血管生物学的新篇章。

环状 RNA (circRNA) 正在成为一类新的非编码 RNA 分子。这种不寻常的 RNA 种类是由一个或两个外显子的反向剪接事件产生的，从而产生一个共价闭合的 circRNA 分子。由于它们的环状形式，circRNA 不受核酸外切酶的降解，并且比线性 RNA 具有更高的稳定性。RNA 测序计算分析的进展表明，数千种不同的 circRNA 在包括心血管系统在内的多种哺乳动物组织中表达。此外，许多 circRNA 以疾病特异性方式表达。在了解这些 circRNA 的生物发生和功能方面取得了很大进展。在这篇综述中，我们讨论了目前对 circRNA 生物发生和功能的理解，

更新日期：2019-05-16

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