CeVO4 Nanozymes Catalyze the Reduction of Dioxygen to Water without Releasing Partially Reduced Oxygen Species.,Angewandte Chemie International Edition

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CeVO4 Nanozymes Catalyze the Reduction of Dioxygen to Water without Releasing Partially Reduced Oxygen Species.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2019-05-06 , DOI: 10.1002/anie.201903427
Namrata Singh _{1,

2} , Govindasamy Mugesh ₁

Affiliation

In this study, we report a remarkably active CeVO₄ nanozyme that functionally mimics cytochrome c oxidase (CcO), the terminal enzyme in the respiratory electron transport chain, by catalyzing a four‐electron reduction of dioxygen to water. The nanozyme catalyzes the reaction by using cytochrome c (Cyt c), the biological electron donor for CcO, at physiologically relevant pH. The CcO activity of the CeVO₄ nanozymes depends on the relative ratio of surface Ce³⁺/Ce⁴⁺ ions, the presence of V⁵⁺ and the surface‐Cyt c interactions. The complete reduction of oxygen to water takes place without release of any partially reduced oxygen species (PROS) such as superoxide, peroxide and hydroxyl radicals.

中文翻译：

CeVO4纳米酶可催化将双氧还原为水，而不释放部分还原的氧气。

在这项研究中，我们报告了一种具有显着活性的CeVO ₄纳米酶，该酶通过催化四电子将双氧还原成水，从而在功能上模仿了细胞色素 c氧化酶（C c O），这是呼吸电子传输链中的末端酶。纳米酶通过在生理相关的pH下使用细胞色素c（Cyt c）（C c O的生物电子供体）催化反应。CeVO ₄纳米酶的C c O活性取决于表面Ce ³⁺ / Ce ⁴⁺离子的相对比例，V ⁵⁺的存在和表面Cyt c互动。氧气完全还原为水，不会释放出任何部分还原的氧气（PROS），例如超氧化物，过氧化物和羟基自由基。

更新日期：2019-05-06

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