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Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis.
Cell Reports ( IF 7.5 ) Pub Date : 2019-04-02 , DOI: 10.1016/j.celrep.2019.03.011 Sara Zumerle 1 , Bianca Calì 1 , Fabio Munari 1 , Roberta Angioni 1 , Francesco Di Virgilio 2 , Barbara Molon 3 , Antonella Viola 1
Cell Reports ( IF 7.5 ) Pub Date : 2019-04-02 , DOI: 10.1016/j.celrep.2019.03.011 Sara Zumerle 1 , Bianca Calì 1 , Fabio Munari 1 , Roberta Angioni 1 , Francesco Di Virgilio 2 , Barbara Molon 3 , Antonella Viola 1
Affiliation
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Extracellular ATP is a signaling molecule exploited by the immune cells for both autocrine regulation and paracrine communication. By performing live calcium imaging experiments, we show that triggered mouse macrophages are able to propagate calcium signals to resting bystander cells by releasing ATP. ATP-based intercellular communication is mediated by P2X4 and P2X7 receptors and is a feature of pro-inflammatory macrophages. In terms of functional significance, ATP signaling is required for efficient phagocytosis of pathogen-derived molecules and apoptotic cells and may represent a target for macrophage regulation by CD39-expressing cells. These results highlight a cell-to-cell communication mechanism tuning innate immunity.
中文翻译：
ATP诱导的细胞间钙信号传导增强巨噬细胞吞噬作用。
细胞外ATP是免疫细胞利用的一种信号分子，用于自分泌调节和旁分泌通讯。通过执行实时钙成像实验，我们表明触发的小鼠巨噬细胞能够通过释放ATP将钙信号传播到静息的旁观者细胞。基于ATP的细胞间通讯是由P2X4和P2X7受体介导的，并且是促炎性巨噬细胞的特征。就功能重要性而言，ATP信号传导是有效吞噬病原体衍生分子和凋亡细胞所必需的，并且可能代表CD39表达细胞调节巨噬细胞的目标。这些结果突显了调节固有免疫力的细胞间通信机制。
更新日期：2019-04-03
中文翻译：
ATP诱导的细胞间钙信号传导增强巨噬细胞吞噬作用。
细胞外ATP是免疫细胞利用的一种信号分子，用于自分泌调节和旁分泌通讯。通过执行实时钙成像实验，我们表明触发的小鼠巨噬细胞能够通过释放ATP将钙信号传播到静息的旁观者细胞。基于ATP的细胞间通讯是由P2X4和P2X7受体介导的，并且是促炎性巨噬细胞的特征。就功能重要性而言，ATP信号传导是有效吞噬病原体衍生分子和凋亡细胞所必需的，并且可能代表CD39表达细胞调节巨噬细胞的目标。这些结果突显了调节固有免疫力的细胞间通信机制。
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