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Advances in injectable self-healing biomedical hydrogels.
Acta Biomaterialia ( IF 9.4 ) Pub Date : 2019-04-03 , DOI: 10.1016/j.actbio.2019.03.057 Yujie Tu 1 , Nuan Chen 2 , Chuping Li 3 , Haiqian Liu 3 , Rong Zhu 3 , Shengfeng Chen 3 , Qiao Xiao 1 , Jianghui Liu 4 , Seeram Ramakrishna 5 , Liumin He 1
Acta Biomaterialia ( IF 9.4 ) Pub Date : 2019-04-03 , DOI: 10.1016/j.actbio.2019.03.057 Yujie Tu 1 , Nuan Chen 2 , Chuping Li 3 , Haiqian Liu 3 , Rong Zhu 3 , Shengfeng Chen 3 , Qiao Xiao 1 , Jianghui Liu 4 , Seeram Ramakrishna 5 , Liumin He 1
Affiliation
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In recent years, implantable biomaterials have attracted significant interest owing to their potentials for use in the therapy of physical defects and traumas. Among the implantable biomaterials, hydrogels have received increasing attention for their tunable structures and good rheological behavior. However, the mechanical failures of traditional gel materials during normal operation remain a serious issue. To overcome this problem, hydrogel materials with self-healing and injectable abilities have been developed, with their potential for autonomous self-recovery and minimally invasive implantation. In this paper, the progress of injectable self-healing hydrogels is presented by combining developments in the fundamental knowledge of polymer designs and discussions on the practical biomedical applications of the materials. The mechanisms of different types of self-healing hydrogels are introduced first and their performances are then discussed, followed by a review of the self-healing hydrogels with injectability. The applications of the injectable self-healing hydrogels are discussed in the final section. STATEMENT OF SIGNIFICANCE: This paper provides an overview of the progress of a smart material, injectable self-healing hydrogel, during the past ten years and mainly focuses on its recent development. This paper presents developments in the fundamental knowledge in polymer designs and discussions on the practical biomedical application of the materials, which sheds more light on the advancement of injectable self-healing hydrogels. This paper should be of interest to the readers who are curious about the advances of injectable self-healing hydrogels.
中文翻译：
注射式自愈生物医学水凝胶的研究进展。
近年来，由于可植入生物材料具有用于治疗身体缺陷和创伤的潜力，因此引起了人们的极大兴趣。在可植入生物材料中，水凝胶因其可调节的结构和良好的流变性能而受到越来越多的关注。然而，传统凝胶材料在正常操作过程中的机械故障仍然是一个严重的问题。为了克服这个问题，已经开发了具有自我修复和可注射能力的水凝胶材料，它们具有自主自我恢复和微创植入的潜力。在本文中，通过结合聚合物设计的基本知识的发展和对材料的实际生物医学应用的讨论，介绍了可注射自愈水凝胶的进展。首先介绍了不同类型的自修复水凝胶的机理，然后讨论了它们的性能，然后对具有注射性的自修复水凝胶进行了综述。最后一部分讨论了可注射的自修复水凝胶的应用。意义声明：本文概述了智能材料，可注射自愈水凝胶在过去十年中的进展，并主要关注其最新发展。本文介绍了聚合物设计方面的基础知识的发展以及有关该材料的实际生物医学应用的讨论，这为可注射自愈水凝胶的发展提供了更多的启示。那些对可注射自愈水凝胶的发展感到好奇的读者应该对本文感兴趣。
更新日期：2019-04-03
中文翻译：
注射式自愈生物医学水凝胶的研究进展。
近年来，由于可植入生物材料具有用于治疗身体缺陷和创伤的潜力，因此引起了人们的极大兴趣。在可植入生物材料中，水凝胶因其可调节的结构和良好的流变性能而受到越来越多的关注。然而，传统凝胶材料在正常操作过程中的机械故障仍然是一个严重的问题。为了克服这个问题，已经开发了具有自我修复和可注射能力的水凝胶材料，它们具有自主自我恢复和微创植入的潜力。在本文中，通过结合聚合物设计的基本知识的发展和对材料的实际生物医学应用的讨论，介绍了可注射自愈水凝胶的进展。首先介绍了不同类型的自修复水凝胶的机理，然后讨论了它们的性能，然后对具有注射性的自修复水凝胶进行了综述。最后一部分讨论了可注射的自修复水凝胶的应用。意义声明：本文概述了智能材料，可注射自愈水凝胶在过去十年中的进展，并主要关注其最新发展。本文介绍了聚合物设计方面的基础知识的发展以及有关该材料的实际生物医学应用的讨论，这为可注射自愈水凝胶的发展提供了更多的启示。那些对可注射自愈水凝胶的发展感到好奇的读者应该对本文感兴趣。
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