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A near-infrared fluorescent probe for imaging endogenous carbon monoxide in living systems with a large Stokes shift
Talanta ( IF 5.6 ) Pub Date : 2019-04-02 , DOI: 10.1016/j.talanta.2019.03.111
Shengyi Gong , Jiaxin Hong , Enbo Zhou , Guoqiang Feng

Near-infrared (NIR) fluorescent probes with a large Stokes shift are very practical tools for bioimaging applications. Carbon monoxide (CO) is a key gaseous signal molecule and its imaging in living systems has attracted great attention in recent years. In this work, a very easy-to-get NIR fluorescent probe with a remarkable large pseudo-Stokes shift (238 nm) for detection of CO was reported. This probe was found to show a rapid NIR fluorescent turn-on response for CO with high selectivity, high sensitivity and a low detection limit (38 nM). Moreover, imaging CO in living cells and animals with this probe was successfully applied with a high signal-to-noise ratio. The results indicate that this probe can be used as a new practical tool for imaging of endogenous CO in living systems.



中文翻译:

斯托克斯频移较大的生物系统中内源性一氧化碳成像的近红外荧光探针

具有大斯托克斯位移的近红外(NIR)荧光探针是用于生物成像应用的非常实用的工具。一氧化碳(CO)是一种重要的气体信号分子,近年来,它在生物系统中的成像备受关注。在这项工作中,报道了一种非常容易获得的NIR荧光探针,具有显着的大伪斯托克斯位移(238 nm),可用于检测CO。发现该探针显示出对CO的快速NIR荧光开启响应,具有高选择性,高灵敏度和低检测限(38 nM)。此外,使用该探针成功地以高信噪比对活细胞和动物中的CO进行了成像。结果表明,该探针可作为生物系统中内源性CO成像的新型实用工具。

更新日期:2019-04-02
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