<br>免疫细胞和淋巴器官的多尺度工程。,Nature Reviews Materials

当前位置： X-MOL 学术 › Nat. Rev. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

免疫细胞和淋巴器官的多尺度工程。
Nature Reviews Materials ( IF 79.8 ) Pub Date : 2019-04-03 , DOI: 10.1038/s41578-019-0100-9
Sungwoong Kim _{1,

2} , Shivem B Shah _{2,

3} , Pamela L Graney _{2,

3,

4} , Ankur Singh _{3,

4,

5}

Affiliation

免疫工程应用定量和基于材料的方法来研究免疫系统并开发针对各种疾病的治疗解决方案，例如感染、癌症、炎症性疾病和与年龄相关的功能障碍。免疫调节和细胞疗法的设计需要精确了解初级、次级和异位三级免疫器官中免疫细胞的形成和激活。然而，免疫系统的研究长期以来仅限于体内方法和二维体外模型，前者通常不允许对细胞内和细胞外过程进行多维控制，而后者缺乏生理相关性。使用合成和天然材料构建的 3D 模型能够重建免疫组织的结构和功能。这些模型正在探索用于研究细胞、组织和器官水平的免疫功能和功能障碍。在这篇综述中，我们讨论了多尺度一级、二级和三级免疫结构工程的 2D 和 3D 方法。我们强调使用这些模型获得的重要见解，并研究免疫疗法设计和开发的多尺度工程策略。最后，研究了动态 4D 材料为免疫器官模型的生成提供刺激依赖性和环境依赖性支架的潜力。

"点击查看英文标题和摘要"

Multiscale engineering of immune cells and lymphoid organs.

Immunoengineering applies quantitative and materials-based approaches for the investigation of the immune system and for the development of therapeutic solutions for various diseases, such as infection, cancer, inflammatory diseases and age-related malfunctions. The design of immunomodulatory and cell therapies requires the precise understanding of immune cell formation and activation in primary, secondary and ectopic tertiary immune organs. However, the study of the immune system has long been limited to in vivo approaches, which often do not allow multidimensional control of intracellular and extracellular processes, and to 2D in vitro models, which lack physiological relevance. 3D models built with synthetic and natural materials enable the structural and functional recreation of immune tissues. These models are being explored for the investigation of immune function and dysfunction at the cell, tissue and organ levels. In this Review, we discuss 2D and 3D approaches for the engineering of primary, secondary and tertiary immune structures at multiple scales. We highlight important insights gained using these models and examine multiscale engineering strategies for the design and development of immunotherapies. Finally, dynamic 4D materials are investigated for their potential to provide stimuli-dependent and context-dependent scaffolds for the generation of immune organ models.

更新日期：2019-05-16

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南