Decoding type I and III interferon signalling during viral infection.,Nature Microbiology

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Decoding type I and III interferon signalling during viral infection.
Nature Microbiology ( IF 20.5 ) Pub Date : 2019-04-01 , DOI: 10.1038/s41564-019-0421-x
Emily V Mesev ₁ , Robert A LeDesma ₁ , Alexander Ploss ₁

Affiliation

Interferon (IFN)-mediated antiviral responses are central to host defence against viral infection. Despite the existence of at least 20 IFNs, there are only three known cell surface receptors. IFN signalling and viral evasion mechanisms form an immensely complex network that differs across species. In this Review, we begin by highlighting some of the advances that have been made towards understanding the complexity of differential IFN signalling inputs and outputs that contribute to antiviral defences. Next, we explore some of the ways viruses can interfere with, or circumvent, these defences. Lastly, we address the largely under-reviewed impact of IFN signalling on host tropism, and we offer perspectives on the future of research into IFN signalling complexity and viral evasion across species.

中文翻译：

解码病毒感染期间的 I 型和 III 型干扰素信号。

干扰素 (IFN) 介导的抗病毒反应是宿主防御病毒感染的核心。尽管存在至少 20 种干扰素，但已知的细胞表面受体只有三种。干扰素信号传导和病毒逃避机制形成了一个极其复杂的网络，该网络因物种而异。在这篇综述中，我们首先强调了在理解有助于抗病毒防御的差异 IFN 信号输入和输出的复杂性方面取得的一些进展。接下来，我们探讨病毒干扰或规避这些防御的一些方式。最后，我们讨论了 IFN 信号传导对宿主向性的影响，这一影响在很大程度上未被充分审查，并且我们对 IFN 信号传导复杂性和跨物种病毒逃避的研究的未来提出了看法。

更新日期：2019-05-16

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