A plasma protein derived TGFβ signature is a prognostic indicator in triple negative breast cancer.,npj Precision Oncology

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A plasma protein derived TGFβ signature is a prognostic indicator in triple negative breast cancer.
npj Precision Oncology ( IF 6.8 ) Pub Date : 2019-04-02 , DOI: 10.1038/s41698-019-0082-5
Hiroyuki Katayama ₁ , Peiling Tsou ₁ , Makoto Kobayashi ₁ , Michela Capello ₁ , Hong Wang ₁ , Francisco Esteva ₂ , Mary L Disis ₃ , Samir Hanash ₁

Affiliation

We investigated the potential of in-depth quantitative plasma proteome analysis to uncover proteins predictive of progression and metastasis in triple negative breast cancer (TNBC). Analysis of samples from 24 pre-menopausal and 24 post-menopausal women with newly diagnosed TNBC who subsequently developed metastasis or remained metastasis free were utilized in the proteomic discovery set, which resulted in 43 proteins associated with tumor progression. These proteins were found to form a hierarchical network with TGFβ. The signature was further confirmed and refined by integrating plasma protein data from a murine TNBC model that encompassed mice with rapid- versus slow-growing tumors. Three genes consisting of CLIC1, MAPRE1, and SERPINA3 in the refined TGFβ signature significantly stratified overall survival (log-rank p = 0.0141) in a larger validation cohort irrespective of menopausal status, tumor stage, grade, and size.

中文翻译：

血浆蛋白衍生的TGFβ标记是三阴性乳腺癌的预后指标。

我们调查了深入定量血浆蛋白质组学分析的潜力，以发现可预测三阴性乳腺癌（TNBC）进展和转移的蛋白质。蛋白质组学发现集中分析了24名新诊断为TNBC的绝经前妇女和24名绝经后妇女的样本，这些妇女随后发生了转移或仍然没有转移，从而产生了43种与肿瘤进展相关的蛋白质。发现这些蛋白质与TGFβ形成分级网络。通过整合来自鼠TNBC模型的血浆蛋白数据进一步确认并完善了签名，该模型涵盖了具有快速生长肿瘤和缓慢生长肿瘤的小鼠。精制的TGFβ标记中由CLIC1，MAPRE1和SERPINA3组成的三个基因显着分层了总体存活率（log-rank p = 0。

更新日期：2019-04-02

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