Biomedical Applications of DNA-Based Molecular Devices.,Advanced Healthcare Materials

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Biomedical Applications of DNA-Based Molecular Devices.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2019-04-02 , DOI: 10.1002/adhm.201801658
Shaoli Liu _{1,

2} , Qiao Jiang ₁ , Yuanning Wang _{1,

3} , Baoquan Ding _{1,

2,

4}

Affiliation

Strict Watson-Crick base pairing and availability by automated synthesis have allowed deoxyribonucleic acid (DNA) molecules to be used as engineerable building blocks for constructing versatile nanostructures. In recent decades, with the development of DNA nanotechnology, a range of DNA-based dynamic molecular devices with sophisticated nanostructures have been designed and constructed. Featuring programmability and biocompatibility, the applications of DNA-based nanodevices have been extensively focused on the interfaces of biological systems. This review summarizes the recent progress in the design of DNA devices exhibiting programmable functions for biomedical applications. In vitro and in vivo applications of DNA-based nanodevices in cellular imaging and systemic drug delivery are highlighted. The challenges and open opportunities are also discussed.

中文翻译：

基于DNA的分子装置的生物医学应用。

严格的Watson-Crick碱基配对和自动合成的可用性已使脱氧核糖核酸（DNA）分子可用作构建通用纳米结构的可工程构建基块。在最近的几十年中，随着DNA纳米技术的发展，已经设计和构建了一系列具有复杂纳米结构的基于DNA的动态分子设备。基于可编程性和生物相容性，基于DNA的纳米器件的应用已广泛地集中在生物系统的界面上。这篇综述总结了在展示针对生物医学应用的可编程功能的DNA装置设计方面的最新进展。着重介绍了基于DNA的纳米器件在细胞成像和全身药物递送中的体外和体内应用。

更新日期：2019-04-02

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