<br>硫化氢：一种气体信号分子调节组织稳态：对眼科疾病的影响。,Cell Death & Disease

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硫化氢：一种气体信号分子调节组织稳态：对眼科疾病的影响。
Cell Death & Disease ( IF 8.1 ) Pub Date : 2019-03-29 , DOI: 10.1038/s41419-019-1525-1
Yuyi Han ₁ , Qianwen Shang ₂ , Jin Yao _{3,

4} , Yong Ji ₅

Affiliation

硫化氢 (H2S) 作为气体递质，调节器官发育和维持组织内稳态。其异常水平与多种人类疾病有关，如神经退行性疾病、心肌损伤和眼科疾病。过量接触H2S可能导致细胞毒性，协调病理过程，并增加各种疾病的风险。有趣的是，在生理状态下，H2S 在维持细胞生理和限制组织损伤方面发挥着关键作用。在哺乳动物中，H2S 的产生由胱硫醚 β-合酶 (CBS)、胱硫醚 γ-裂解酶 (CSE)、3-巯基甲硫基丙酮酸转氨酶 (3MST) 和半胱氨酸转氨酶 (CAT) 催化。这些酶存在于哺乳动物眼球内的不同位置。它们的异常表达以及底物和中间体的积累可以使 H2S 的水平改变几个数量级，导致眼睛的结构或功能异常。详细研究表明，H2S供体的给药可以通过调节眼组织细胞内或细胞外蛋白质的功能来调节眼内压、保护视网膜细胞、抑制氧化应激并减轻炎症。因此，几种缓慢释放的 H2S 供体已被证明是治疗多种疾病的有前途的药物。在这篇综述中，我们讨论了H2S代谢的生物学功能及其在眼科疾病中的应用。

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Hydrogen sulfide: a gaseous signaling molecule modulates tissue homeostasis: implications in ophthalmic diseases.

Hydrogen sulfide (H2S) serves as a gasotransmitter in the regulation of organ development and maintenance of homeostasis in tissues. Its abnormal levels are associated with multiple human diseases, such as neurodegenerative disease, myocardial injury, and ophthalmic diseases. Excessive exposure to H2S could lead to cellular toxicity, orchestrate pathological process, and increase the risk of various diseases. Interestingly, under physiological status, H2S plays a critical role in maintaining cellular physiology and limiting damages to tissues. In mammalian species, the generation of H2S is catalyzed by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), 3-mercapto-methylthio pyruvate aminotransferase (3MST) and cysteine aminotransferase (CAT). These enzymes are found inside the mammalian eyeballs at different locations. Their aberrant expression and the accumulation of substrates and intermediates can change the level of H2S by orders of magnitude, causing abnormal structures or functions in the eyes. Detailed investigations have demonstrated that H2S donors' administration could regulate intraocular pressure, protect retinal cells, inhibit oxidative stress and alleviate inflammation by modulating the function of intra or extracellular proteins in ocular tissues. Thus, several slow-releasing H2S donors have been shown to be promising drugs for treating multiple diseases. In this review, we discuss the biological function of H2S metabolism and its application in ophthalmic diseases.

更新日期：2019-04-01

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