tert-Butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a green and chemoselective N-tert-butoxycarbonylation reagent†,New Journal of Chemistry

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tert-Butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a green and chemoselective N-tert-butoxycarbonylation reagent†
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2019-03-27 00:00:00 , DOI: 10.1039/c9nj00885c
Fangyu Du _{1,

2,

3,

4} , Qifan Zhou _{1,

2,

3,

4} , Yang Fu _{1,

2,

3,

4} , Hanqi Zhao _{1,

2,

3,

4} , Yuanguang Chen _{1,

2,

3,

4} , Guoliang Chen _{1,

2,

3,

4}

Affiliation

The use of tert-butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a chemoselective tert-butoxycarbonylation reagent for aromatic and aliphatic amines has been demonstrated. To gain insight into this reaction, in situ React IR technology was used to confirm the effectivity and chemoselectivity of this novel Boc reagent. The reaction was carried out chemoselectively in high yield under mild, environment-friendly conditions and was completed quickly within 1 hour. Simultaneously, the Boc carrier was easily recyclable, and has great application prospects for industrial production.

中文翻译：

叔丁基（3-氰基-4,6-二甲基吡啶-2-基）碳酸酯，为绿色和化学选择性N-叔-butoxycarbonylation试剂†

已证明使用（3-氰基-4，6-二甲基吡啶-2-基）碳酸叔丁酯作为芳族和脂族胺的化学选择性叔丁氧基羰基化试剂。为了深入了解该反应，使用了原位反应红外技术来确认这种新型Boc试剂的有效性和化学选择性。反应在温和，环境友好的条件下以高产率进行化学选择性反应，并在1小时内迅速完成。同时，Boc载体易于回收利用，在工业生产中具有广阔的应用前景。

更新日期：2019-03-27

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