Four novel zinc complexes, namely [Zn(oxa)₂(MeOH)₄] (1), [Zn(oxa)₂(H₂O)(bipy)]·MeOH·2.5H₂O (2·MeOH·2.5H₂O), [Zn(oxa)₂(bipyam)]·1.25MeOH (3·1.25MeOH) and [Zn(oxa)₂(phen)] (4), with the non-steroidal anti-inflammatory drug oxaprozin (Hoxa) and a N,N′-donor heterocyclic ligand, such as 2,2′‑bipyridylamine (bipyam), 1,10‑phenanthroline (phen) or 2,2′‑bipyridine (bipy), were characterized with physicochemical techniques, various spectroscopies and single-crystal X-ray crystallography. In these coordination compounds, the oxaprozin ligands are coordinated to zinc ion in a monodentate or a bidentate chelating binding mode. The antioxidant activity of the complexes was evaluated via their ability to scavenge in vitro 1,1‑diphenyl‑2‑picrylhydrazyl, hydroxyl and 2,2′‑azinobis‑(3‑ethylbenzothiazoline‑6‑sulfonic acid) radicals. The complexes bind to calf-thymus DNA via intercalation as suggested via a series of studies employing UV–vis spectroscopy, DNA-viscosity measurements and competition with ethidium bromide. The complexes may bind to serum albumins tightly and reversibly in order to get transferred through the bloodstream.

四种新型锌配合物，即[Zn（oxa）₂（MeOH）₄ ]（1），[Zn（oxa）₂（H ₂ O）（bipy）]·MeOH·2.5H ₂ O（2 ·MeOH·2.5H ₂ O），[Zn（oxa）₂（联苯胺）]·1.25MeOH（3 ·1.25MeOH）和[Zn（oxa）₂（phen）]（4），以及非甾体抗炎药oxaprozin（Hoxa ）和N，N通过物理化学技术，各种分光光度法和单晶X表征了'供体杂环配体，例如2,2'-联吡啶胺（bipyam），1,10-菲咯啉（phen）或2,2'-联吡啶（bipy）射线晶体学。在这些配位化合物中，奥沙普嗪配体以单齿或双齿螯合结合方式与锌离子配位。通过其清除体外1,1-二苯基-2-吡啶甲基肼基，羟基和2,2'-叠氮基双（3-乙基苯并噻唑啉-6-磺酸）基团的能力来评估复合物的抗氧化活性。结合的小牛胸腺DNA的复合物通过插层的建议经由使用紫外可见光谱，DNA粘度测量以及与溴化乙锭竞争的一系列研究。该复合物可以紧密和可逆地与血清白蛋白结合，以便通过血流转移。