Genetically Encoded Biotin Analogues: Incorporation and Application in Bacterial and Mammalian Cells.,ChemBioChem

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Genetically Encoded Biotin Analogues: Incorporation and Application in Bacterial and Mammalian Cells.
ChemBioChem ( IF 2.6 ) Pub Date : 2019-06-26 , DOI: 10.1002/cbic.201900015
Adrian Hohl _{1,

2} , Yonatan G Mideksa _{2,

3} , Ram Karan ₁ , Anastassja Akal _{1,

2} , Malvina Vogler ₁ , Michael Groll ₂ , Magnus Rueping ₁ , Kathrin Lang _{2,

3} , Matthias J Feige _{2,

3} , Jörg Eppinger ₁

Affiliation

Controlled interactions: Genetically encoded biotin and 2‐iminobiotin lysine provide stringent control over the site of modification and stoichiometry. Well‐defined biotinylated proteins can potentially simplify protein investigation, protein immobilization, and the production of protein–drug conjugates through the strong interaction to streptavidin.