Cryptosporidiosis, an enteric protozoon, causes substantial morbidity and mortality associated with diarrhea in children <2 years old in low- to middle-income countries. There is no vaccine and treatments are inadequate. A piperazine-based compound, MMV665917, has in vitro and in vivo efficacy against Cryptosporidium parvum. In this study, we evaluated the efficacy of MMV665917 in gnotobiotic piglets experimentally infected with Cryptosporidium hominis, the species responsible for >75% of diarrhea reported in these children.

中文翻译：

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哌嗪衍生物MMV665917：在人隐隐孢子虫腹泻小猪模型中的有效药物。

隐孢子虫病是一种肠病原虫，在中低收入国家中使2岁以下儿童的腹泻引起大量发病和死亡。没有疫苗，治疗不足。基于哌嗪的化合物MMV665917具有体外和体内抵抗小隐孢子虫的功效。在这项研究中，我们评估了MMV665917在实验性感染人隐隐孢子虫的致癌仔猪中的功效，这些隐孢子虫导致这些儿童的腹泻率> 75％。