多层双功能SiO2 @ Au @ SiO2 @ QD纳米粒子，可同时进行细胞内加热和温度测量。,Langmuir

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多层双功能SiO2 @ Au @ SiO2 @ QD纳米粒子，可同时进行细胞内加热和温度测量。
Langmuir ( IF 3.7 ) Pub Date : 2019-03-19 00:00:00 , DOI: 10.1021/acs.langmuir.8b04263
Xinbing Jiang ₁ , Ben Q Li ₂ , Xiaoli Qu ₁ , Huan Yang ₁ , Jinyou Shao ₁ , Hongmei Zhang ₃

Affiliation

本文讨论了双功能SiO ₂ @ [email protected] _2的合成及应用。QD复合纳米颗粒，用于集成带温度驱动的细胞内加热。颗粒具有多层同心结构，由覆盖有量子点的Au纳米壳组成，前者用于通过局部表面等离子体共振进行红外加热，而后者用于温度监控。将等离子体加热/热监控集成在单个复合纳米颗粒上的关键是确保量子点与Au壳表面相距一定距离，以确保可检测的量子产率。量子点直接附着到Au壳上将使量子点在温度监控中几乎不起作用。要将量子点集成到Au纳米壳中，即SiO ₂的量子猝灭势垒是通过修改类似于Stöber的流程创建的。这些复合纳米粒子的材料，光学和热学表征。讨论了纳米颗粒的细胞摄取。在用双功能SiO ₂ @ [电子邮件保护的] ₂ @QD复合纳米粒子内化的细胞中，进行了同时体外加热和温度监测的实验。

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Multilayered Dual Functional SiO2@Au@SiO2@QD Nanoparticles for Simultaneous Intracellular Heating and Temperature Measurement.

This paper discusses synthesis and application of dual functional SiO₂@[email protected]₂@QD composite nanoparticles for integrated intracellular heating with temperature motoring. The particles are of multilayered concentric structure, consisting of Au nanoshells covered with quantum dots, with the former for infrared heating through localized surface plasma resonance while the later for temperature monitoring. The key to integrate plasmonic-heating/thermal-monitoring on a single composite nanoparticle is to ensure that the quantum dots be separated at a certain distance away from the Au shell surface in order to ensure a detectable quantum yield. Direct attachment of the quantum dots onto the Au shell would render the quantum dots practically functionless for temperature monitoring. To integrate quantum dots into Au nanoshells, a quantum quenching barrier of SiO₂ was created by modifying a Stöber-like process. Materials, optical and thermal characterization was made of these composite nanoparticles. Cellular uptake of the nanoparticles was discussed. Experiments were performed on simultaneous in vitro heating and temperature monitoring in a cell internalized with the dual-functional SiO₂@[email protected]₂@QD composite nanoparticles.

更新日期：2019-03-19

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