Automated Glycan Assembly: A Perspective,Journal of the American Chemical Society

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Automated Glycan Assembly: A Perspective
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2019-03-19 , DOI: 10.1021/jacs.9b00638
Mónica Guberman _{1,

2} , Peter H Seeberger ₁

Affiliation

The intrinsic complexity of carbohydrate structures has hampered access to pure glycans and hence impeded progress in the glycosciences. Automated Glycan Assembly (AGA) has facilitated the procurement of synthetic glycans, to be used in diagnostics, vaccine development, enzyme characterization and structure–function relationship studies. A general approach for obtaining complex glycans from mammalian, bacterial, fungal and plant classes provides molecular tools for glycobiology research. Recent advances in AGA technology pave the way for the production of novel carbohydrate materials. This perspective describes the state-of-the art of AGA and aspects of the technology where additional improvements are needed.

中文翻译：

自动化糖链组装：一个观点

碳水化合物结构的内在复杂性阻碍了获得纯聚糖，从而阻碍了糖科学的进步。自动糖链组装 (AGA) 促进了合成糖链的采购，用于诊断、疫苗开发、酶表征和结构-功能关系研究。从哺乳动物、细菌、真菌和植物类别中获取复杂聚糖的通用方法为糖生物学研究提供了分子工具。AGA 技术的最新进展为生产新型碳水化合物材料铺平了道路。这个观点描述了 AGA 的最新技术以及需要进一步改进的技术方面。

更新日期：2019-03-19

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