Regulatory T cell adaptation in the intestine and skin.,Nature Immunology

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Regulatory T cell adaptation in the intestine and skin.
Nature Immunology ( IF 27.7 ) Pub Date : 2019-03-19 , DOI: 10.1038/s41590-019-0351-z
Natasha Whibley ₁ , Andrea Tucci ₁ , Fiona Powrie ₁

Affiliation

The intestine and skin are distinct microenvironments with unique physiological functions and are continually exposed to diverse environmental challenges. Host adaptation at these sites is an active process that involves interaction between immune cells and tissue cells. Regulatory T cells (Treg cells) play a pivotal role in enforcing homeostasis at barrier surfaces, illustrated by the development of intestinal and skin inflammation in diseases caused by primary deficiency in Treg cells. Treg cells at barrier sites are phenotypically distinct from their lymphoid-organ counterparts, and these 'tissue' signatures often reflect their tissue-adapted function. We discuss current understanding of Treg cell adaptation in the intestine and skin, including unique phenotypes, functions and metabolic demands, and how increased knowledge of Treg cells at barrier sites might guide precision medicine therapies.

中文翻译：

肠道和皮肤中的调节性T细胞适应性。

肠道和皮肤是具有独特生理功能的独特微环境，并不断暴露于各种环境挑战中。这些部位的宿主适应是一个活跃的过程，涉及免疫细胞和组织细胞之间的相互作用。调节性T细胞（Treg细胞）在加强屏障表面的稳态中起着关键作用，这由Treg细胞原发性缺乏引起的肠道和皮肤炎症的发展说明。屏障位点的Treg细胞在表型上与淋巴器官对应物不同，并且这些“组织”特征经常反映出它们的组织适应性功能。我们讨论了当前对肠道和皮肤中Treg细胞适应性的理解，包括独特的表型，功能和代谢需求，

更新日期：2019-05-16

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