对H <sub>2</sub> S说不：HNO，HSNO和SSNO的故事<sup>–</sup>,Inorganic Chemistry

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对H ₂ S说不：HNO，HSNO和SSNO的故事^–
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2019-03-18 00:00:00 , DOI: 10.1021/acs.inorgchem.8b02592
Ivana Ivanovic-Burmazovic ₁ , Milos R. Filipovic _{2,

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Affiliation

无机小分子之间的相互作用对于理解基本反应机理以及有机分子之前并导致生命起源的化学演化的一些初始过程至关重要。这些过程的动力学适合于快速生成各种新的化学实体，以及级联化学反应的传播，这是即使在生物系统中也非常适合发信号的特性。NO和H ₂ S是当今公认的通过蛋白质修饰（例如S）参与调节生理功能的生物气体递质的分子。-亚硝基硫醇，二硫化物和过硫化物的形成。在此观点下，我们回顾了化学和生化背景下NO（以及有机和金属亚硝酰基物质）与H ₂ S相互作用的最新理解。通过形成HNO，（H）SNO（及其异构体），（H）SSNO和多硫化物，这两种气体递质启动了在细胞信号转导中起重要作用的反应网络。这些氮和硫物种的化学反应性和生物学效应仍未解决，因此，它们之间的相互影响代表了一个充满挑战的跨学科领域，等待令人振奋的新发现。我们解决了一些有趣且开放的问题，并为未来的研究方向提供了见解。

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Saying NO to H2S: A Story of HNO, HSNO, and SSNO–

Interactions between small inorganic molecules are fundamental to the understanding of basic reaction mechanisms and some of the initial processes of chemical evolution that preceded organic molecules and led to the origin of life. The kinetics of these processes are suitable for the fast generation of a variety of new chemical entities and the propagation of a cascade of chemical reactions, a property that is ideal for signaling purposes even in biological systems. NO and H₂S are such molecules that are nowadays recognized as biological gasotransmitters involved in the regulation of physiological functions through protein modifications such as S-nitrosothiol, disulfide, and persulfide formations. In this Viewpoint, we review the current understanding of interactions of NO (and organic and metal nitrosyl species) with H₂S, in both chemical and biochemical contexts. Through the formation of HNO, (H)SNO (and its isomers), (H)SSNO, and polysulfides, these two gasotransmitters initiate reaction networks with significant roles in cell signaling. The chemical reactivities and biological effects of these nitrogen and sulfur species are still unresolved, and, thus, a cross-talk between all of them represents a challenging interdisciplinary field that awaits exciting new findings. We tackle some of the intriguing and open questions and provide perspectives for future research directions.

更新日期：2019-03-18

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