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Cell migration promotes dynamic cellular interactions to control cerebral cortex morphogenesis.
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2019-06-01 , DOI: 10.1038/s41583-019-0148-y Carla G Silva 1 , Elise Peyre 1 , Laurent Nguyen 1
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2019-06-01 , DOI: 10.1038/s41583-019-0148-y Carla G Silva 1 , Elise Peyre 1 , Laurent Nguyen 1
Affiliation
The cerebral cortex is an evolutionarily advanced brain structure that computes higher motor, sensory and cognitive functions. Its complex organization reflects the exquisite cell migration and differentiation patterns that take place during embryogenesis. Recent evidence supports an essential role for cell migration in shaping the developing cerebral cortex via direct cellular contacts and spatially organized diffusible cues that regulate the establishment of its cytoarchitecture and function. Identifying the nature of the crosstalk between cell populations at play during brain development is key to understanding how cerebral cortical morphogenesis proceeds in health and disease.
中文翻译:
细胞迁移促进动态细胞相互作用,以控制大脑皮层形态发生。
大脑皮层是进化高级的大脑结构,可计算出更高的运动,感觉和认知功能。它的复杂组织反映了在胚胎发生过程中发生的精致的细胞迁移和分化模式。最近的证据支持细胞迁移通过直接的细胞接触和调节其细胞结构和功能建立的空间组织的可扩散线索,在塑造发育中的大脑皮层中起着至关重要的作用。识别大脑发育过程中正在发挥作用的细胞群之间串扰的性质,对于理解大脑皮层形态发生如何在健康和疾病中发展至关重要。
更新日期:2019-05-16
中文翻译:
细胞迁移促进动态细胞相互作用,以控制大脑皮层形态发生。
大脑皮层是进化高级的大脑结构,可计算出更高的运动,感觉和认知功能。它的复杂组织反映了在胚胎发生过程中发生的精致的细胞迁移和分化模式。最近的证据支持细胞迁移通过直接的细胞接触和调节其细胞结构和功能建立的空间组织的可扩散线索,在塑造发育中的大脑皮层中起着至关重要的作用。识别大脑发育过程中正在发挥作用的细胞群之间串扰的性质,对于理解大脑皮层形态发生如何在健康和疾病中发展至关重要。