Breast Cancer is the most diffuse cancer among women and the treatment outcome is largely determined by its early detection. MRI at fixed magnetic field is already widely used for cancer detection. Herein it is shown that the acquisition of proton T₁ at different magnetic fields adds further advantages. In fact, Fast Field Cycling Nuclear Magnetic Resonance Dispersion (FFC-NMRD) profiles have been shown to act as a high –sensitivity tool for cancer detection and staging in ex vivo murine breast tissues collected from Balb/NeuT mice. From NMRD profiles it was possible to extract two new cancer biomarkers, namely: (i) the appearance of ¹⁴N-quadrupolar peaks (QPs) reporting on tumor onset and (ii) the slope of the NMRD profile reporting on the progression of the tumor. By this approach it was possible to detect the presence of tumor in transgenic NeuT mice at a very early stage (5–7 weeks), when the disease is not yet detectable by using conventional high field (7 T) MRI and only minimal abnormalities are present in histological assays. These results show that, NMRD profiles may represent a useful tool for early breast cancer detection and for getting more insight into an accurate tumor phenotyping, highlighting changes in composition of the mammary gland tissue (lipids/proteins/water) occurring during the development of the neoplasia.

乳腺癌是女性中最扩散的癌症，治疗结果很大程度上取决于早期发现。固定磁场下的MRI已经广泛用于癌症检测。在此表明，在不同的磁场下获取质子T ₁进一步增加了优点。实际上，已证明快速场循环核磁共振弥散（FFC-NMRD）谱可作为从Balb / NeuT小鼠收集的离体鼠乳腺组织中癌症检测和分期的高灵敏度工具。从NMRD谱图中可以提取出两种新的癌症生物标记，即：（i）^14种报告肿瘤发作的N四极峰（QP）和（ii）报告肿瘤进展的NMRD图谱的斜率。通过这种方法，可以在很早的阶段（5-7周）检测转基因NeuT小鼠中肿瘤的存在，当时该疾病无法通过常规的高场（7 T）MRI检测到，并且只有极少的异常是可以检测到的存在于组织学检测中。这些结果表明，NMRD谱图可能代表早期乳腺癌检测和深入了解准确的肿瘤表型的有用工具，突出显示了在乳腺发育过程中发生的乳腺组织成分（脂质/蛋白质/水）的变化。瘤形成。