Programmable Electrofabrication of Porous Janus Films with Tunable Janus Balance for Anisotropic Cell Guidance and Tissue Regeneration,Advanced Functional Materials

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Programmable Electrofabrication of Porous Janus Films with Tunable Janus Balance for Anisotropic Cell Guidance and Tissue Regeneration
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2019-03-11 , DOI: 10.1002/adfm.201900065
Miao Lei ₁ , Xue Qu ₁ , Huan Liu ₁ , Yi Liu ₂ , Shijia Wang ₁ , Shang Wu ₂ , William E. Bentley ₂ , Gregory F. Payne ₂ , Changsheng Liu ₁

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Janus films with controlled pore structures can be particularly important in diverse applications. There remains a challenge for simple, rapid, and scalable fabrication methods to control Janus balance (JB) including the thickness of the individual face as well as porosity and pore size. Here the electrofabrication of a porous Janus film with controlled Janus balance from aminopolysaccharide chitosan under the salt effect is reported. Sequential deposition of chitosan under programmable salt environment and electrochemical conditions enables construction of Janus films with precisely controlled Janus balance. Bioactive partially soluble calcium phosphate (CaP) salts can also generate porous structure in Janus film. It is specifically reported that a chitosan/hydroxyl apatite (HAp) composite Janus film can serve as an effective scaffold for guided bone regeneration. The dense layer functions to provide mechanical support and serves as a barrier for fibrous connective tissue penetration. The porous composite layer functions to provide the microenvironment for osteogenesis. In vivo studies using a rat calvarial defect model confirm the beneficial features of this Janus composite for guided bone regeneration. These results suggest the potential of electrofabrication as a simple and scalable platform technology to tune the self‐organization of soft matter for a range of emerging applications.

中文翻译：

具有可调Janus平衡的多孔Janus膜的可编程电加工，用于各向异性细胞引导和组织再生

具有受控孔结构的Janus膜在各种应用中尤其重要。对于简单，快速和可扩展的制造方法来控制Janus平衡（JB）包括单个面的厚度以及孔隙率和孔径，仍然存在挑战。在此，报道了在盐作用下由氨基多糖壳聚糖电加工具有可控Janus平衡的多孔Janus膜的方法。在可编程的盐环境和电化学条件下，壳聚糖的顺序沉积能够构建具有精确控制的Janus平衡的Janus膜。具有生物活性的部分可溶性磷酸钙（CaP）盐也可以在Janus膜中产生多孔结构。专门报道了壳聚糖/羟基磷灰石（HAp）复合Janus膜可以用作引导骨骼再生的有效支架。致密层起到提供机械支撑的作用，并用作纤维结缔组织穿透的屏障。多孔复合层的功能是为成骨提供微环境。使用大鼠颅盖骨缺损模型的体内研究证实了这种Janus复合材料对引导性骨再生的有益功能。这些结果表明，电加工作为一种简单且可扩展的平台技术具有潜力，可以为一系列新兴应用调整软物质的自组织。多孔复合层的功能是为成骨提供微环境。使用大鼠颅盖骨缺损模型的体内研究证实了这种Janus复合材料对引导性骨再生的有益功能。这些结果表明，电加工作为一种简单且可扩展的平台技术具有潜力，可以为一系列新兴应用调整软物质的自组织。多孔复合层的功能是为成骨提供微环境。使用大鼠颅盖骨缺损模型的体内研究证实了这种Janus复合材料对引导性骨再生的有益功能。这些结果表明，电加工作为一种简单且可扩展的平台技术具有潜力，可以为一系列新兴应用调整软物质的自组织。

更新日期：2019-03-11

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