Migratory Reductive Acylation between Alkyl Halides or Alkenes and Alkyl Carboxylic Acids by Nickel Catalysis,ACS Catalysis

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Migratory Reductive Acylation between Alkyl Halides or Alkenes and Alkyl Carboxylic Acids by Nickel Catalysis
ACS Catalysis ( IF 11.3 ) Pub Date : 2019-03-11 00:00:00 , DOI: 10.1021/acscatal.9b00521
Jun He ₁ , Peihong Song ₁ , Xianfeng Xu ₁ , Shaolin Zhu ₁ , You Wang ₁

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A mild migratory reductive acyl cross-coupling has been achieved through NiH-catalyzed chainwalking and subsequent cross-coupling from two abundant starting materials, alkyl bromides, and carboxylic acids. This strategy allows the direct acylation of the benzylic sp³ C–H bond with high yield as a single regioisomer. As an alternative, the alkyl bromide could be replaced by the proposed olefin intermediate and commercially available n-PrBr to achieve a remote hydroacylation process.

中文翻译：

镍催化的卤代烷或烯烃与烷基羧酸之间的迁移还原酰化

通过NiH催化的链走反应以及随后从两种丰富的起始原料（烷基溴化物和羧酸）的交叉偶联，实现了温和的迁移性还原性酰基交叉偶联。这种策略可以将苄基sp ³ C–H键直接酰化，并以高收率作为单一的区域异构体。作为替代，烷基溴可以用提出的烯烃中间体和可商购的正-PrBr代替，以实现远程加氢酰化过程。

更新日期：2019-03-11

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