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pH-responsive catalytic mesocrystals for chemodynamic therapy via ultrasound-assisted Fenton reaction
Chemical Engineering Journal ( IF 13.3 ) Pub Date : 2019-03-08 , DOI: 10.1016/j.cej.2019.03.061
Jian Chen , Xiaobo Wang , Yibiao Liu , Huili Liu , Fengli Gao , Chong Lan , Baocheng Yang , Shouren Zhang , Yongju Gao

We develop pH-responsive [email protected]3-Fe3O4 particles as catalytic nanomedicine for chemodynamic therapy through ultrasound-assisted Fenton reaction. By loading glucose oxidase (GOD) in the interior of the particles, GOD can be well protected and effectively delivered to catalyze glucose in cancer cells. A considerable amount of H2O2 is then generated for Fenton reaction by reacting with Fe3O4 nanoparticles. The introduction of ultrasound irradiation can significantly improve Fenton reaction efficiency in tumors owing to ultrasonic cavitation. Highly toxic hydroxyl radicals are then generated in abundance to kill cancer cells. Good cancer therapeutic effect was realized both in vitro and in vivo via this ultrasound-chemodynamic strategy based on the designed particles, providing a novel strategy for efficient cancer therapy.



中文翻译:

pH响应催化介​​晶,用于通过超声辅助的Fenton反应进行化学动力学治疗

我们开发pH响应[受电子邮件保护的] 3 -Fe 3 O 4颗粒作为催化纳米药物,用于通过超声辅助的Fenton反应进行化学动力学治疗。通过在颗粒内部装载葡萄糖氧化酶(GOD),可以很好地保护GOD,并有效地输送GOD以催化癌细胞中的葡萄糖。然后通过与Fe 3 O 4反应生成大量的H 2 O 2用于Fenton反应。纳米粒子。由于超声空化作用,超声辐射的引入可以显着提高肿瘤中的Fenton反应效率。然后大量产生高毒性的羟基自由基以杀死癌细胞。通过基于设计粒子的超声化学动力学策略,在体内外都实现了良好的癌症治疗效果,为有效的癌症治疗提供了新的策略。

更新日期:2019-03-08
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