A One‐Pot Ring‐Opening/Ring‐Closure Sequence for the Synthesis of Polycyclic Spirooxindoles,Chemistry - A European Journal

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A One‐Pot Ring‐Opening/Ring‐Closure Sequence for the Synthesis of Polycyclic Spirooxindoles
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2019-03-06 , DOI: 10.1002/chem.201900409
Ji‐Wei Ren ₁ , Qing‐Lan Zhao ₁ , Jun‐An Xiao ₂ , Peng‐Ju Xia ₁ , Hao‐Yue Xiang ₁ , Xiao‐Qing Chen ₁ , Hua Yang ₁

Affiliation

One‐pot ring‐opening/ring‐closure process of combining methyleneindolinone with 3‐aminooxindole has been developed in this work. Novel polycyclic spirooxindoles were efficiently assembled under mild conditions in high yields (up to 95 %) with moderate to good diastereoselectivities (up to >95:5 d.r.) through simple filtration.

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