5-(Chloromethyl)furfural (CMF) is a carbohydrate-derived platform molecule that is gaining traction as a more practical alternative to 5-(hydroxymethyl)furfural (HMF). This perspective introduces the chemocatalytic approach to biorefining as the driving force behind the development of multifunctional chemical platforms. The main advantage of CMF over HMF is that it can be produced in high yield under mild conditions directly from raw biomass. Its stability and hydrophobicity markedly facilitate isolation. CMF is also a precursor to levulinic acid (LA), another versatile biobased intermediate. The logistics of CMF production are discussed, including reactor materials, HCl handling and management, byproducts, and the fate of collateral biomass components (hemicellulose, lipids, proteins, lignin). Examples of commercial markets that can be unlocked by synthetic manipulation of CMF are broken out into two derivative manifolds, furanic and levulinic, which are distributed over three product family trees: renewable monomers, fuels, and specialty chemicals. Selected examples of CMF- and LA-based routes to these products are presented. Finally, a model for the integration of the CMF process into biorefinery practice is put forward.

中文翻译：

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5-（氯甲基）糠醛（CMF）：将纤维素转化为商品的平台

5-（氯甲基）糠醛（CMF）是一种源自碳水化合物的平台分子，它作为5-（羟甲基）糠醛（HMF）的更实用替代品而日益受到关注。该观点介绍了化学催化方法进行生物精制，作为多功能化学平台开发背后的推动力。CMF优于HMF的主要优势在于，它可以在温和的条件下直接由原始生物质以高收率生产。其稳定性和疏水性显着促进了分离。CMF还是另一种通用的生物基中间体乙酰丙酸（LA）的前体。讨论了CMF生产的物流，包括反应器材料，HCl处理和管理，副产品以及附带的生物质成分（半纤维素，脂质，蛋白质，木质素）的去向。可以通过CMF的合成操纵来释放的商业市场的示例分为两个衍生分支，即呋喃和乙酰丙酸，分布在三种产品族谱中：可再生单体，燃料和特种化学品。给出了基于CMF和LA的路线通往这些产品的部分示例。最后，提出了将CMF工艺整合到生物炼制实践中的模型。