当前位置: X-MOL 学术J. Mater. Chem. B › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Bio-related applications of porous organic frameworks (POFs).
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2019-03-19 , DOI: 10.1039/c8tb03192d
He Zhang 1 , Guoliang Li , Chunyang Liao , Yaqi Cai , Guibin Jiang
Affiliation  

Increasing attention has been given to the field of porous organic frameworks (POFs) due to their unique properties, outstanding performance, and broad applications. Given their extremely high surface area, ordered crystal structure, and ease of tailoring, POFs are promising candidates for gas adsorption and separation, catalysis, supercapacitors, chemosensors, and bio-related applications. Furthermore, their tunable pore size and high agent loading capacity make them promising candidates for drug delivery, whereas their ease of functionalization leads to target specificity and long blood circulation times, which are important properties in bioimaging. For biosensing applications, the pores and channels of POFs can accommodate target molecules and induce specific recognition. POFs can also be applied in phototherapy in combination with photosensitizers. Finally, POF-based artificial shells can encapsulate bioactive molecules and strengthen the resistance of cells to adverse environmental conditions. In this review, we will highlight the research progress of POF-based bio-related applications, including drug delivery, bioimaging, biosensing agents, as well as in phototherapy and artificial shells. Furthermore, the in vitro and in vivo toxicological studies of POFs are discussed as are the prospects and future research directions for POFs in bio-related applications.

中文翻译:

多孔有机框架 (POF) 的生物相关应用。

多孔有机框架(POFs)由于其独特的性质、突出的性能和广泛的应用而受到越来越多的关注。鉴于其极高的表面积、有序的晶体结构和易于定制,POF 是气体吸附和分离、催化、超级电容器、化学传感器和生物相关应用的有前途的候选者。此外,它们可调的孔径和高药剂负载能力使它们成为药物输送的有前途的候选者,而它们易于功能化导致目标特异性和血液循环时间长,这是生物成像中的重要特性。对于生物传感应用,POF 的孔和通道可以容纳目标分子并诱导特异性识别。POF 还可以与光敏剂结合应用于光疗中。最后,基于 POF 的人造外壳可以封装生物活性分子,增强细胞对不利环境条件的抵抗力。在这篇综述中,我们将重点介绍基于 POF 的生物相关应用的研究进展,包括药物输送、生物成像、生物传感剂,以及光疗和人造外壳。此外,还讨论了 POF 的体外和体内毒理学研究,以及 POF 在生物相关应用中的前景和未来研究方向。包括药物输送、生物成像、生物传感剂,以及光疗和人造外壳。此外,还讨论了 POF 的体外和体内毒理学研究,以及 POF 在生物相关应用中的前景和未来研究方向。包括药物输送、生物成像、生物传感剂,以及光疗和人造外壳。此外,还讨论了 POF 的体外和体内毒理学研究,以及 POF 在生物相关应用中的前景和未来研究方向。
更新日期:2019-03-06
down
wechat
bug