垂直的椎间盘倾斜和视神经头部解剖结构的特征与近视眼的视野缺损有关。,Scientific Reports

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垂直的椎间盘倾斜和视神经头部解剖结构的特征与近视眼的视野缺损有关。
Scientific Reports ( IF 3.8 ) Pub Date : 2019-03-05 , DOI: 10.1038/s41598-019-38960-6
Hae-Young Lopilly Park ₁ , Yong Chan Kim ₁ , Younhea Jung ₂ , Chan Kee Park ₁

Affiliation

近视是与青光眼等各种眼科疾病相伴而来的严重增长的眼部疾病。了解近视眼中观察到的视野（VF）和视网膜神经纤维层（RNFL）损伤很重要。因此，我们使用光谱域（SD）光学相干断层扫描（OCT）评估了视盘边缘解剖结构。我们在无红光照片和OCT中纳入了40例健康的近视患者和64例具有视神经节上鼻区域RNFL缺陷的近视患者。视盘立体照片共定位于SD-OCT图像，并且我们分析了在照片中识别出的视盘边缘与布鲁赫膜（BM）开口，BM /边界组织或边界组织相吻合的频率。对于每次扫描，边界组织的存在都超出了临床椎间盘边缘和Bruch'末端的范围。膜被鉴定。在64只具有RNFL缺陷的近视眼中，有42只具有相应的颞下VF缺陷。25％至60％的近视眼在所有时钟位置均出现边界组织突出。然而，在有VF缺陷的近视眼中，在1点，2点，11点和12点的位置发现边界组织悬垂的比例为86％至97％。这与近视健康的眼睛明显不同。我们建议视盘边缘的OCT结构可能会导致近视患者的VF损伤。这与近视健康的眼睛明显不同。我们建议视盘边缘的OCT结构可能会导致近视患者的VF损伤。这与近视健康的眼睛明显不同。我们建议视盘边缘的OCT结构可能会导致近视患者的VF损伤。

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Vertical disc tilt and features of the optic nerve head anatomy are related to visual field defect in myopic eyes.

Myopia is significantly growing eye disease which accompanies various ocular pathologies including glaucoma. Understanding visual field (VF) and retinal nerve fiber layer (RNFL) damage observed in myopic eyes is important. Therefore, we evaluated optic disc margin anatomy using spectral-domain (SD) optical coherence tomography (OCT). We enrolled 40 healthy myopic patients and 64 myopic patients with RNFL defects in the superonasal region of the optic disc on red-free photographs and OCT. Optic disc stereophotographs were co-localized to SD-OCT images, and we analyzed the frequency with which the disc margin identified in photographs coincided with Bruch's membrane (BM) opening, BM/border tissue, or border tissue. For each scan, the presence of border tissue overhang beyond the clinical disc margin and the end of Bruch's membrane was identified. Among 64 myopic eyes with RNFL defects, 42 had corresponding inferotemporal VF defects. Border tissue overhang was found from 25 to 60% of myopic eyes with RNFL defect at all clock positions. However, border tissue overhang was found from 86 to 97% at 1, 2, 11 and 12 o'clock position in myopic eyes with VF defects. This was significantly different from myopic healthy eyes. We suggest that the OCT structure at the disc margin might contribute to VF damage in myopic patients.

更新日期：2019-03-05

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