Oligosaccharides self-assemble and show intrinsic optical properties,Journal of the American Chemical Society

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Oligosaccharides self-assemble and show intrinsic optical properties
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2019-03-04 , DOI: 10.1021/jacs.8b11882
Yang Yu _{1,

2} , Soeun Gim _{1,

2} , Dongyoon Kim ₁ , Zohar A Arnon ₃ , Ehud Gazit _{3,

4} , Peter H Seeberger _{1,

2} , Martina Delbianco ₁

Affiliation

Self-assembling peptides and oligonucleotides have given rise to synthetic materials with several applications in nanotechnology. Aggregation of synthetic oligosaccharides into well-defined architectures has not been reported even though natural polysaccharides, such as cellulose and chitin, are key structural components of biomaterials. Here, we report that six synthetic oligosaccharides, ranging from dimers to hexamers, self-assemble into nanostructures of varying morphologies and emit within the visible spectrum in an excitation-dependent manner. Well-defined differences in chain length, monomer modification, and aggregation methods yield glycomaterials with distinct shapes and properties. The excitation-dependent fluorescence in a broad range within the visible spectrum illustrates their potential for use in optical devices and imaging applications. We anticipate that our systematic approach of studying well-defined synthetic oligosaccharides will form the foundation of our understanding of carbohydrate interactions in nature.

中文翻译：

低聚糖自组装并显示出固有的光学特性

自组装肽和寡核苷酸已经产生了在纳米技术中具有多种应用的合成材料。尽管天然多糖（如纤维素和几丁质）是生物材料的关键结构成分，但尚未报道合成低聚糖聚集成明确定义的结构。在这里，我们报告了六种合成寡糖，从二聚体到六聚体，自组装成不同形态的纳米结构，并以依赖于激发的方式在可见光谱内发射。链长、单体修饰和聚合方法的明确差异产生具有不同形状和特性的糖材料。可见光谱范围内的激发依赖性荧光说明了它们在光学设备和成像应用中的应用潜力。我们预计，我们研究定义明确的合成寡糖的系统方法将成为我们理解自然界中碳水化合物相互作用的基础。

更新日期：2019-03-04

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