(−)-Hydroxycitric Acid Suppresses Lipid Droplet Accumulation and Accelerates Energy Metabolism via Activation of the Adiponectin-AMPK Signaling Pathway in Broiler Chickens,Journal of Agricultural and Food Chemistry

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(−)-Hydroxycitric Acid Suppresses Lipid Droplet Accumulation and Accelerates Energy Metabolism via Activation of the Adiponectin-AMPK Signaling Pathway in Broiler Chickens
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2019-03-02 00:00:00 , DOI: 10.1021/acs.jafc.8b07287
Longlong Li _{1,

2} , Huihui Zhang _{1,

2} , Yao Yao _{1,

2} , Zhongmiao Yang _{1,

2} , Haitian Ma _{1,

2}

Affiliation

(−)-Hydroxycitric acid (HCA) inhibits the deposition of fat in animals and humans, while the molecular mechanism is still unclear. The present study investigated the effect and mechanism of (−)-HCA’s regulation of lipid, glucose, and energy metabolism in broiler chickens. The current results showed that (−)-HCA decreased the accumulation of lipid droplets and triglyceride content by reducing fatty acid synthase protein level and enhancing phosphorylation of acetyl-CoA carboxylase protein level. (−)-HCA accelerated carbohydrate aerobic metabolisms by increasing the activities of phosphofructokinase-1, pyruvate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase. Furthermore, (−)-HCA increased adiponectin receptor 1 mRNA level and enhanced phospho-AMPKα, peroxisome proliferator-activated receptor gamma coactivator-1α, nuclear respiratory factor-1, and mitochondrial transcription factor A protein levels in broiler chickens. These data indicated that (−)-HCA reduced lipid droplet accumulation, improved glucose catabolism, and accelerated energy metabolism in broiler chickens, possibly via activation of adiponectin-AMPK signaling pathway. These results revealed the biochemical mechanism of (−)-HCA-mediated fat accumulation and the prevention of metabolic disorder-related diseases in broiler chickens.

中文翻译：

（-）-羟基柠檬酸通过激活脂联素-AMPK信号转导通路抑制肉鸡血脂的积累并加速能量代谢

（-）-羟基柠檬酸（HCA）抑制动物和人类中脂肪的沉积，但分子机理尚不清楚。本研究调查了（-）-HCA调节肉鸡体内脂质，葡萄糖和能量代谢的作用和机理。目前的结果表明，（-）-HCA通过降低脂肪酸合酶蛋白水平和增强乙酰辅酶A羧化酶蛋白水平的磷酸化作用，减少了脂质滴的积累和甘油三酸酯的含量。（-）-HCA通过增加磷酸果糖激酶-1，丙酮酸脱氢酶，琥珀酸脱氢酶和苹果酸脱氢酶的活性来加速碳水化合物有氧代谢。此外，（-）-HCA增加了脂联素受体1 mRNA的水平，并增强了过氧化物酶体增殖物激活的受体gammacoactivator-1α的磷酸-AMPKα，肉鸡的核呼吸因子-1和线粒体转录因子A蛋白水平。这些数据表明，（-）-HCA可能通过激活脂联素-AMPK信号传导途径而降低了肉鸡中的脂滴积聚，改善了葡萄糖的分解代谢并加速了能量代谢。这些结果揭示了肉鸡中（-）-HCA介导的脂肪积聚的生化机制和代谢紊乱相关疾病的预防。

更新日期：2019-03-02

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