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Photoacoustic-imaging-guided therapy of functionalized melanin nanoparticles: combination of photothermal ablation and gene therapy against laryngeal squamous cell carcinoma†
Nanoscale ( IF 5.8 ) Pub Date : 2019-03-01 00:00:00 , DOI: 10.1039/c9nr01122f Bo Fan 1, 2, 3, 4 , Xi Yang 3, 4, 5 , Xiaoyan Li 2, 3, 4 , Shuxin Lv 2, 3, 4 , Huanhu Zhang 3, 4, 5 , Jinghua Sun 2, 3, 4 , Liping Li 2, 3, 4 , Lingjie Wang 2, 3, 4 , Botao Qu 2, 3, 4 , Xiaoyang Peng 2, 3, 4 , Ruiping Zhang 1, 2, 3, 4, 5
Nanoscale ( IF 5.8 ) Pub Date : 2019-03-01 00:00:00 , DOI: 10.1039/c9nr01122f Bo Fan 1, 2, 3, 4 , Xi Yang 3, 4, 5 , Xiaoyan Li 2, 3, 4 , Shuxin Lv 2, 3, 4 , Huanhu Zhang 3, 4, 5 , Jinghua Sun 2, 3, 4 , Liping Li 2, 3, 4 , Lingjie Wang 2, 3, 4 , Botao Qu 2, 3, 4 , Xiaoyang Peng 2, 3, 4 , Ruiping Zhang 1, 2, 3, 4, 5
Affiliation
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Multimodality therapy under imaging-guidance is significant to improve the accuracy of cancer treatment. In this study, a photoacoustic imaging (PAI)-guided anticancer strategy based on poly-L-lysine functionalized melanin nanoparticles (MNP-PLL) was developed to treat laryngeal squamous cell carcinoma (LSCC). As a promising alternative to traditional therapies for LSCC, MNP-PLL/miRNA nanoparticles were combined with photothermal ablation against primary tumors and miR-145-5p mediated gene therapy for depleting the metastatic potential of tumor cells. Furthermore, taking advantage of the photoacoustic properties of melanin, PAI guided therapy could optimize the time point of NIR irradiation to maximize the efficacy of photothermal therapy (PTT). The in vitro and in vivo results proved that the combined treatments displayed the most significant tumor suppression compared with monotherapy. By integrating thermo-gene therapies into a theranostic nanoplatform, the MNP-PLL/miR-145-5p nanoparticles significantly suppressed the LSCC progression, indicating their great potential use for cancer therapy.
中文翻译：
功能化黑色素纳米粒子的光声成像引导疗法：光热消融和基因治疗相结合的喉鳞状细胞癌†
影像引导下的多模态治疗对提高癌症治疗的准确性具有重要意义。在这项研究中，开发了一种基于聚L-赖氨酸功能化黑色素纳米粒子（MNP-PLL）的光声成像（PAI）指导的抗癌策略，以治疗喉鳞状细胞癌（LSCC）。作为对LSCC的传统疗法有希望的替代方法，MNP-PLL / miRNA纳米粒子与针对原发性肿瘤的光热消融以及miR-145-5p介导的基因治疗相结合，以耗尽肿瘤细胞的转移潜能。此外，利用黑色素的光声特性，PAI引导疗法可以优化NIR照射的时间点，从而最大化光热疗法（PTT）的功效。在体外和体内结果证明，与单一疗法相比，联合疗法显示出最显着的肿瘤抑制作用。通过将热基因疗法整合到治疗的纳米平台中，MNP-PLL / miR-145-5p纳米粒子显着抑制了LSCC进程，表明其在癌症疗法中的巨大潜力。
更新日期：2019-03-01
中文翻译：
功能化黑色素纳米粒子的光声成像引导疗法：光热消融和基因治疗相结合的喉鳞状细胞癌†
影像引导下的多模态治疗对提高癌症治疗的准确性具有重要意义。在这项研究中，开发了一种基于聚L-赖氨酸功能化黑色素纳米粒子（MNP-PLL）的光声成像（PAI）指导的抗癌策略，以治疗喉鳞状细胞癌（LSCC）。作为对LSCC的传统疗法有希望的替代方法，MNP-PLL / miRNA纳米粒子与针对原发性肿瘤的光热消融以及miR-145-5p介导的基因治疗相结合，以耗尽肿瘤细胞的转移潜能。此外，利用黑色素的光声特性，PAI引导疗法可以优化NIR照射的时间点，从而最大化光热疗法（PTT）的功效。在体外和体内结果证明，与单一疗法相比，联合疗法显示出最显着的肿瘤抑制作用。通过将热基因疗法整合到治疗的纳米平台中，MNP-PLL / miR-145-5p纳米粒子显着抑制了LSCC进程，表明其在癌症疗法中的巨大潜力。
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