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Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception.
Nature Communications ( IF 14.7 ) Pub Date : 2019-02-28 , DOI: 10.1038/s41467-019-08873-z
Linette Liqi Tan 1 , Manfred Josef Oswald 1 , Céline Heinl 1 , Oscar Andrés Retana Romero 1 , Sanjeev Kumar Kaushalya 1 , Hannah Monyer 2 , Rohini Kuner 1
Affiliation  

In humans, gamma-band oscillations in the primary somatosensory cortex (S1) correlate with subjective pain perception. However, functional contributions to pain and the nature of underlying circuits are unclear. Here we report that gamma oscillations, but not other rhythms, are specifically strengthened independently of any motor component in the S1 cortex of mice during nociception. Moreover, mice with inflammatory pain show elevated resting gamma and alpha activity and increased gamma power in response to sub-threshold stimuli, in association with behavioral nociceptive hypersensitivity. Inducing gamma oscillations via optogenetic activation of parvalbumin-expressing inhibitory interneurons in the S1 cortex enhances nociceptive sensitivity and induces aversive avoidance behavior. Activity mapping identified a network of prefrontal cortical and subcortical centers whilst morphological tracing and pharmacological studies demonstrate the requirement of descending serotonergic facilitatory pathways in these pain-related behaviors. This study thus describes a mechanistic framework for modulation of pain by specific activity patterns in the S1 cortex.

中文翻译:

体感皮层中的伽马振荡在厌恶和伤害感受中募集前额叶和递减的血清素能途径。

在人类中,主要体感皮层(S1)中的γ波段振荡与主观疼痛感相关。但是,对疼痛的功能性贡献和潜在回路的性质尚不清楚。在这里,我们报告说,在伤害感受期间,γ振荡(而不是其他节律)会特别增强,与小鼠S1皮质中的任何运动成分无关。此外,与行为伤害性超敏反应有关,患有炎性疼痛的小鼠表现出升高的静息伽马和α活性以及对亚阈值刺激的增强的伽马能力。通过S1皮质中表达小白蛋白的抑制性中间神经元的光遗传激活来诱导伽马振荡,可以增强伤害感受性并引起厌恶回避行为。活动图谱确定了前额叶皮层和皮层下中心的网络,而形态追踪和药理研究表明,在这些与疼痛有关的行为中,需要降级血清素能促进途径。因此,这项研究描述了一种通过S1皮质特定活动模式调节疼痛的机制框架。
更新日期:2019-02-28
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