Expedient synthesis of a symmetric cycloheptyne-Co2(CO)6 complex for orthogonal Huisgen cycloadditions†,Organic Chemistry Frontiers

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Expedient synthesis of a symmetric cycloheptyne-Co2(CO)6 complex for orthogonal Huisgen cycloadditions†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2019-02-28 00:00:00 , DOI: 10.1039/c9qo00086k
Morgan Cormier _{1,

2,

3,

4} , Eric Fouquet _{1,

2,

3,

4} , Philippe Hermange _{1,

2,

3,

4}

Affiliation

A short procedure to prepare a cycloheptyne di-cobalt-carbonyl complex functionalised by a terminal alkyne is reported. This symmetric complex can react selectively in Strain Promoted Alkyne Azide Cycloaddition (SPAAC) or Copper Catalysed Alkyne Azide Cycloaddition (CuAAC) depending on the conditions, providing a new and practical tool for orthogonal conjugation reactions with azido reagents.

中文翻译：

对称的Huisgen环加成反应的对称环庚炔-Co ₂（CO）_6配合物的便捷合成†

报道了一种制备由末端炔官能化的环庚炔二钴羰基配合物的短程序。这种对称的络合物可以根据条件在应变促进的乙炔叠氮化物环加成反应（SPAAC）或铜催化的乙炔叠氮化物环加成反应（CuAAC）中选择性反应，为与叠氮试剂进行正交偶联反应提供了一种新的实用工具。

更新日期：2019-02-28

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