Heterogeneity of neutrophils.,Nature Reviews Immunology

当前位置： X-MOL 学术 › Nat. Rev. Immunol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Heterogeneity of neutrophils.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2019-04-01 , DOI: 10.1038/s41577-019-0141-8
Lai Guan Ng ₁ , Renato Ostuni _{2,

3} , Andrés Hidalgo _{4,

5}

Affiliation

Structured models of ontogenic, phenotypic and functional diversity have been instrumental for a renewed understanding of the biology of immune cells, such as macrophages and lymphoid cells. However, there are no established models that can be used to define the diversity of neutrophils, the most abundant myeloid cells. This lack of an established model is largely due to the uniquely short lives of neutrophils, a consequence of their inability to divide once terminally differentiated, which has been perceived as a roadblock to functional diversity. This perception is rapidly evolving as multiple phenotypic and functional variants of neutrophils have been found, both in homeostatic and disease conditions. In this Opinion article, we present an overview of neutrophil heterogeneity and discuss possible mechanisms of diversification, including genomic regulation. We suggest that neutrophil heterogeneity is an important feature of immune pathophysiology, such that co-option of the mechanisms of diversification by cancer or other disorders contributes to disease progression.

中文翻译：

中性粒细胞的异质性。

本体论，表型和功能多样性的结构化模型有助于重新认识免疫细胞（例如巨噬细胞和淋巴样细胞）的生物学特性。但是，没有建立的模型可用于定义嗜中性粒细胞（最丰富的骨髓细胞）的多样性。缺乏建立的模型主要是由于嗜中性粒细胞生命周期短，这是由于嗜中性粒细胞一旦终末分化就无法分裂，这被认为是功能多样性的障碍。由于在稳态和疾病状态下都发现了嗜中性粒细胞的多种表型和功能变异，因此这种观念正在迅速发展。在这篇“意见”文章中，我们概述了中性粒细胞异质性，并讨论了多样化的可能机制，包括基因组调控。我们建议中性粒细胞异质性是免疫病理生理学的重要特征，因此癌症或其他疾病的多样化机制的共同选择有助于疾病进展。

更新日期：2019-07-05

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南