Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster.,The Journal of Antibiotics

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Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2019-02-28 , DOI: 10.1038/s41429-019-0161-4
Chunshuai Huang _{1,

2} , Chunfang Yang ₁ , Wenjun Zhang ₁ , Yiguang Zhu ₁ , Liang Ma ₁ , Zhuangjie Fang _{1,

2} , Changsheng Zhang _{1,

2}

Affiliation

Heterologous expression of the fluostatin biosynthetic gene cluster from the marine-derived Micromonospora rosaria SCSIO N160 in Streptomyces albus J1074 led to the isolation of a novel isoindolequinone albumycin (1) and a known isoquinolinequinone mansouramycin A (2). The structure of 1 was elucidated on the basis of detailed 1D and 2D NMR spectroscopic analysis. Mansouramycin A (2) is active against methicillin-resistant Staphylococcus aureus ATCC 43300, with a MIC of 8 μg ml-1, while albumycin (1) displayed negligible antibacterial activities. This study represents another example of activation of secondary metabolites that are non-relevant to the heterologously introduced biosynthetic gene cluster in a bacterial host.

中文翻译：

白霉素，一种来自 Streptomyces albus J1074 的新异吲哚醌，含有氟抑素生物合成基因簇。

来自海洋来源的罗氏小单孢菌 SCSIO N160 的氟抑制素生物合成基因簇在 Streptomyces albus J1074 中的异源表达导致分离出一种新型异吲哚醌白霉素 (1) 和一种已知的异喹啉醌甘露霉素 A (2)。1的结构是在详细的一维和二维核磁共振光谱分析的基础上阐明的。Mansouramycin A (2) 对耐甲氧西林金黄色葡萄球菌 ATCC 43300 具有活性，MIC 为 8 μg ml-1，而白霉素 (1) 的抗菌活性可以忽略不计。该研究代表了与细菌宿主中异源引入的生物合成基因簇无关的次级代谢物活化的另一个例子。

更新日期：2019-07-05

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