Identification of bioactive metabolites using activity metabolomics.,Nature Reviews Molecular Cell Biology

当前位置： X-MOL 学术 › Nat. Rev. Mol. Cell Biol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Identification of bioactive metabolites using activity metabolomics.
Nature Reviews Molecular Cell Biology ( IF 81.3 ) Pub Date : 2019-06-01 , DOI: 10.1038/s41580-019-0108-4
Markus M Rinschen ₁ , Julijana Ivanisevic ₂ , Martin Giera ₃ , Gary Siuzdak ₁

Affiliation

The metabolome, the collection of small-molecule chemical entities involved in metabolism, has traditionally been studied with the aim of identifying biomarkers in the diagnosis and prediction of disease. However, the value of metabolome analysis (metabolomics) has been redefined from a simple biomarker identification tool to a technology for the discovery of active drivers of biological processes. It is now clear that the metabolome affects cellular physiology through modulation of other 'omics' levels, including the genome, epigenome, transcriptome and proteome. In this Review, we focus on recent progress in using metabolomics to understand how the metabolome influences other omics and, by extension, to reveal the active role of metabolites in physiology and disease. This concept of utilizing metabolomics to perform activity screens to identify biologically active metabolites - which we term activity metabolomics - is already having a broad impact on biology.

中文翻译：

使用活性代谢组学鉴定生物活性代谢物。

代谢组是参与代谢的小分子化学实体的集合，传统上研究的目的是识别疾病诊断和预测中的生物标志物。然而，代谢组分析（代谢组学）的价值已从简单的生物标志物识别工具重新定义为发现生物过程主动驱动因素的技术。现在很清楚，代谢组通过调节其他“组学”水平（包括基因组、表观基因组、转录组和蛋白质组）来影响细胞生理学。在这篇综述中，我们重点关注利用代谢组学来了解代谢组学如何影响其他组学，并进而揭示代谢物在生理学和疾病中的积极作用的最新进展。利用代谢组学进行活性筛选以鉴定生物活性代谢物的概念（我们称之为活性代谢组学）已经对生物学产生了广泛的影响。

更新日期：2019-07-05

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南