3D Printing of Poly(propylene fumarate) Oligomers: Evaluation of Resin Viscosity, Printing Characteristics and Mechanical Properties.,Biomacromolecules

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3D Printing of Poly(propylene fumarate) Oligomers: Evaluation of Resin Viscosity, Printing Characteristics and Mechanical Properties.
Biomacromolecules ( IF 5.5 ) Pub Date : 2019-03-12 , DOI: 10.1021/acs.biomac.9b00076
Yuanyuan Luo ₁ , Gaëlle Le Fer ₁ , David Dean ₂ , Matthew L Becker ₁

Affiliation

Complex three-dimensional (3D) pore geometries, useful for tissue engineering scaffolds, can be fabricated via photo-crosslinking of resorbable poly(propylene fumarate) (PPF) resins using stereolithography (SLA) and/or continuous digital light processing (cDLP) methods. Physico-chemical parameters inherent to 3D printable resin design, include viscosity, polymer concentration, degree of polymerization, and resin printing temperature. We report here on our study of these parameters and their influence the cDLP 3D printing process and the resulting mechanical properties. A series of PPF oligomers were synthesized by the ring-opening copolymerization (ROCOP) of maleic anhydride and propylene oxide followed by a base-catalyzed isomerization. The resin viscosities were measured as a function of number-average molecular mass ([Formula: see text]) of the PPF oligomers (1.1, 1.7 and 2.0 kDa), concentrations of PPF in the reactive diluent diethyl fumarate (DEF) (50 and 75 wt %) and resin temperature (25 to 55 °C). The zero-shear viscosity (η0) of the resins was found to be temperature-dependent and follow a linear Arrhenius relationship. Tensile tests demonstrated mechanical properties within the range of trabecular bone, with the ultimate strength at break above 15 MPa and elastic moduli between 178 and 199 MPa.

中文翻译：

聚（富马酸丙二醇酯）低聚物的3D打印：树脂粘度，印刷特性和机械性能的评估。

可通过立体光刻（SLA）和/或连续数字光处理（cDLP）方法通过可吸收性聚富马酸丙二酯（PPF）树脂的光交联来制造对组织工程支架有用的复杂三维（3D）孔几何形状。3D可打印树脂设计固有的物理化学参数包括粘度，聚合物浓度，聚合度和树脂印刷温度。我们在这里报告了我们对这些参数的研究及其对cDLP 3D打印过程及其产生的机械性能的影响。通过马来酸酐和环氧丙烷的开环共聚（ROCOP），然后进行碱催化的异构化反应，合成了一系列PPF低聚物。测得的树脂粘度是数均分子量的函数（[分子式：PPF低聚物（1.1、1.7和2.0 kDa），反应性稀释剂富马酸二乙酯（DEF）中的PPF浓度（50和75 wt％）和树脂温度（25至55°C）。发现树脂的零剪切粘度（η0）与温度有关，并且遵循线性阿伦尼乌斯（Arrhenius）关系。拉伸试验表明其力学性能在小梁骨范围内，断裂时的极限强度高于15 MPa，弹性模量在178至199 MPa之间。

更新日期：2019-02-26

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