Wearable biosensors are garnering substantial interest due to their potential to provide continuous, real-time physiological information via dynamic, noninvasive measurements of biochemical markers in biofluids, such as sweat, tears, saliva and interstitial fluid. Recent developments have focused on electrochemical and optical biosensors, together with advances in the noninvasive monitoring of biomarkers including metabolites, bacteria and hormones. A combination of multiplexed biosensing, microfluidic sampling and transport systems have been integrated, miniaturized and combined with flexible materials for improved wearability and ease of operation. Although wearable biosensors hold promise, a better understanding of the correlations between analyte concentrations in the blood and noninvasive biofluids is needed to improve reliability. An expanded set of on-body bioaffinity assays and more sensing strategies are needed to make more biomarkers accessible to monitoring. Large-cohort validation studies of wearable biosensor performance will be needed to underpin clinical acceptance. Accurate and reliable real-time sensing of physiological information using wearable biosensor technologies would have a broad impact on our daily lives.

由于可穿戴生物传感器具有通过动态，非侵入性测量生物流体中生化标记（例如汗液，眼泪，唾液和间质液）的能力来提供连续，实时的生理信息的潜力，因此引起了广泛的关注。近期的发展集中在电化学和光学生物传感器上，以及对包括代谢物，细菌和激素在内的生物标志物的无创监测方面的进展。多重生物传感，微流体采样和运输系统的组合已经集成，小型化并与柔性材料组合在一起，以提高耐磨性和操作简便性。尽管可穿戴生物传感器有望实现，但仍需要更好地了解血液中分析物浓度与非侵入性生物流体之间的相关性，以提高可靠性。需要更多的体内生物亲和力检测方法和更多的传感策略，以使更多的生物标记物可用于监测。需要对可穿戴生物传感器性能进行大范围的验证研究，以支持临床接受度。使用可穿戴生物传感器技术准确，可靠地实时感测生理信息将对我们的日常生活产生广泛影响。