Intestinal Barrier Function–Non-alcoholic Fatty Liver Disease Interactions and Possible Role of Gut Microbiota,Journal of Agricultural and Food Chemistry

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Intestinal Barrier Function–Non-alcoholic Fatty Liver Disease Interactions and Possible Role of Gut Microbiota
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2019-02-25 00:00:00 , DOI: 10.1021/acs.jafc.9b00080
Yizhe Cui ₁ , Qiuju Wang ₁ , Renxu Chang ₁ , Xiaocui Zhou ₂ , Chuang Xu ₁

Affiliation

Non-alcoholic fatty liver disease (NAFLD) is a metabolic stress liver injury that is closely related to obesity, insulin resistance, type 2 diabetes, atherosclerosis, and metabolic syndrome. The pathological features are diffuse hepatic vesicular steatosis, including non-alcoholic steatohepatitis, liver fibrosis, and even liver cancer. A variety of pathological outcomes cause serious harm to human health. At present, an increasing number of researchers are investigating the pathogenesis of NAFLD from the perspective of changes in the function of the intestinal barrier. The physical, chemical, immunological, and microbiological barriers in the intestinal tract constitute the complete intestinal barrier, which plays an important defensive role against the invasion of harmful substances from the intestines. Protecting the function of the intestinal barrier is a new way to treat NAFLD and its related diseases. In this perspective, we summarized the current knowledge of the role of the intestinal barrier in NAFLD.

中文翻译：

肠屏障功能-非酒精性脂肪肝疾病的相互作用和肠道菌群的可能作用

非酒精性脂肪肝疾病（NAFLD）是一种代谢应激性肝损伤，与肥胖，胰岛素抵抗，2型糖尿病，动脉粥样硬化和代谢综合征密切相关。病理特征是弥漫性肝囊性脂肪变性，包括非酒精性脂肪性肝炎，肝纤维化，甚至肝癌。各种病理结果严重危害人类健康。目前，越来越多的研究人员正在从肠屏障功能变化的角度研究NAFLD的发病机理。肠道中的物理，化学，免疫学和微生物屏障构成了完整的肠道屏障，在防御有害物质从肠道入侵方面起着重要的防御作用。保护肠屏障功能是治疗NAFLD及其相关疾病的新方法。从这个角度出发，我们总结了肠屏障在NAFLD中的作用的当前知识。

更新日期：2019-02-25

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