Self-Assembly of Stable Nanoscale Platelets from Designed Elastin-like Peptide-Collagen-like Peptide Bioconjugates.,Biomacromolecules

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Self-Assembly of Stable Nanoscale Platelets from Designed Elastin-like Peptide-Collagen-like Peptide Bioconjugates.
Biomacromolecules ( IF 5.5 ) Pub Date : 2019-03-06 , DOI: 10.1021/acs.biomac.8b01681
Jingya Qin ₁ , Tianzhi Luo ₁ , Kristi L Kiick _{1,

2}

Affiliation

The self-assembly of nanostructures from elastin-like (poly)peptide (ELP) containing block copolymers has been a subject of intense investigation over decades. However, short synthetic ELPs have rarely been used due to their high inverse transition temperature; the use of short ELPs has largely been limited to polymer conjugates. Motivated by our previous work which successfully overcame this barrier by simply conjugating short ELPs with a triple-helix-forming collagen-like peptide, in this study, we further extend the ELP library to a series of ELPs equipped with aromatic residues and having sequences as short as four pentapeptide motifs. The resulting elastin-like peptide-collagen-like peptide (ELP-CLP) bioconjugates unexpectedly self-assembled into nanosized platelets likely by forming a bilayer structure. Given the previously demonstrated ability of many other CLP conjugates to target collagens and the potential for encapsulation of hydrophobic drugs in collapsed ELPs, these ELP-CLP nanoplatelets may offer similar opportunities for targeted delivery in biomedical and other arenas.

中文翻译：

从设计的弹性蛋白样肽-胶原蛋白样肽生物缀合物中稳定的纳米级血小板的自组装。

由包含弹性蛋白的（聚）肽（ELP）的嵌段共聚物形成的纳米结构的自组装已成为数十年来研究的热点。但是，短合成ELP由于其较高的逆转变温度而很少使用。短ELP的使用在很大程度上限于聚合物共轭物。由于我们以前的工作成功地克服了这一障碍，该研究通过简单地将短ELP与形成三螺旋的胶原蛋白样肽结合而成功克服了这一障碍，在本研究中，我们将ELP文库进一步扩展到一系列配备有芳香族残基并具有以下序列的ELP：短至四个五肽基序。所得的弹性蛋白样肽-胶原蛋白样肽（ELP-CLP）生物缀合物出乎意料地自组装成纳米级血小板，可能是通过形成双层结构。

更新日期：2019-02-21

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